Prospective Multicenter Screening for Thoracic Disease Via Radiography
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Pulmonary Diseases, Respiratory Disease, Esophageal Diseases. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Thoracic Disease Screening Via Radiography: a Prospective Multicenter Study
Overview
This multicenter, prospective study aims to evaluate the real-world clinical utility of chest X-ray (CXR) for large-scale thoracic disease screening. Adult participants presenting for health examinations will undergo digital CXR screening, and any suspected abnormalities will be confirmed via a gold standard reference, such as a chest CT scan or clinical follow-up. The primary outcome measure is the detection rate (screening yield) of confirmed thoracic conditions. Secondary measures will assess diagnostic accuracy (sensitivity and specificity), false-positive rates, and multi-center reading consistency. By providing prospective, large-cohort evidence, this research seeks to validate the cost-effectiveness and feasibility of CXR in identifying early-stage lung, pleural, and cardiac abnormalities, ultimately guiding public health strategies and optimizing early medical intervention.
Primary outcome measures
- Overall Detection Rate of Thoracic Diseases [Time frame: Through study completion, an average of 1 year.]
- Screening Yield [Time frame: Through study completion, an average of 1 year.]
Secondary outcome measures (3)
- Diagnostic Performance Metrics [Time frame: Through study completion, an average of 1 year.]
- Multi-center Consistency and Inter-reader Reliability [Time frame: Through study completion, an average of 1 year.]
- Disease-Specific Detection Rates [Time frame: Through study completion, an average of 1 year.]
Eligibility criteria
Inclusion criteria
- Age over 18.
- Ability to understand and willingness to sign a written informed consent form.
- Individuals presenting for routine health examinations or community-based screening.
Exclusion criteria
- Women who are pregnant, lactating, or planning to become pregnant during the study period.
- Physical limitations preventing stable positioning or breath-holding, or presence of metallic implants that may significantly degrade image quality.
- Known history of advanced thoracic diseases currently under treatment (e.g., active lung cancer, end-stage pulmonary fibrosis, or congestive heart failure).
- Individuals who have undergone chest CT or X-ray examinations within the past 3 months.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Dazhou Central Hospital — Dazhou
Identifiers
NCT: NCT07585214 · PROMPT