Effect of High-Intensity Laser Therapy on Femoral Cartilage in Knee Osteoarthritis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: High-Intensity Laser Therapy (HILT) + Conventional Physiotherapy, Conventional Physiotherapy.
- Who it may be relevant to
- Registry conditions: Osteoarthritis (OA) of the Knee, Osteoarthitis. Basic parameters: 40 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Pakistan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Role of High-intensity Laser Therapy on Femoral Cartilage Thickness in Patients With Knee Osteoarthritis
Overview
This clinical trial will evaluate the effects of High-Intensity Laser Therapy (HILT) on femoral cartilage thickness and other clinical outcomes in people with knee osteoarthritis. Participants aged 40 to 60 years with grade II or III knee osteoarthritis will be randomly assigned to receive either HILT plus conventional physiotherapy or conventional physiotherapy alone. Both groups will receive 12 treatment sessions on alternate days for 4 weeks. The study will assess changes in cartilage thickness using ultrasound, as well as improvements in pain, knee movement, muscle strength, and daily function. Findings from this research may help improve physiotherapy treatment strategies for patients with knee osteoarthritis.
Interventions
- Device High-Intensity Laser Therapy (HILT) + Conventional Physiotherapy
HILT will be administered using a Class IV laser applied perpendicularly at eight standardized knee points. Both analgesic and biostimulation modes will be used.. Sessions will be conducted on alternate days for 4 weeks (12 sessions total). - Other Conventional Physiotherapy
Conventional physiotherapy includes hot moist pack application, manual joint mobilization, stretching, and strengthening exercises for quadriceps and hamstrings. Sessions will be held on alternate days for 4 weeks (12 sessions total).
Primary outcome measures
- Femoral Cartilage Thickness [Time frame: Baseline, Week 4]
Secondary outcome measures (5)
- Pain Intensity [Time frame: Baseline, Week 2, Week 4]
- Western Ontario and McMaster Universities Arthritis Index (WOMAC) [Time frame: Baseline, Week 2, Week 4]
- Knee Range of Motion (ROM) [Time frame: Baseline, Week 2, Week 4]
- One-Leg Stance Test [Time frame: Baseline, Week 2, Week 4]
- Quadriceps Muscle Strength [Time frame: Baseline, Week 2, Week 4]
Eligibility criteria
Inclusion criteria
- Male and female participants aged 40-60 years.
- Diagnosed with knee osteoarthritis (Kellgren-Lawrence grade II or III).
- Knee pain for at least 3 months.
- Visual Analogue Scale (VAS) score ≥ 3.
- Willing to provide written informed consent and comply with treatment and follow-up schedule.
Exclusion criteria
- History of knee surgery or traumatic knee injury.
- Inflammatory arthritis (e.g., gout, psoriatic arthritis).
- History of cancer or psychiatric illness.
- Cognitive disorders (e.g., Parkinson's disease, Alzheimer's disease).
- Severe comorbidities limiting exercise (e.g., severe COPD, heart failure, cerebrovascular event).
- Hip or ankle joint disability.
- Intra-articular knee injection within the past 3 months.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Pakistan · 1 center
- London Aesthetics and Rejuvenation Center — Lahore
Identifiers
NCT: NCT07584603 · UOL/IREB/25/12/0033