Impact of the Procurement Technique on Outcomes After Liver Transplantation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Liver Transplantation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Impact of the Procurement Technique on Outcomes After Liver Transplantation: a French Multicenter Prospective Study
Overview
Liver transplantation (LT) is the standard treatment for hepatocellular carcinoma (HCC) and end-stage liver disease, with excellent long-term outcomes despite the increasing use of extended criteria donors due to organ shortage. As traditional evaluation criteria have become insufficient, new indicators such as Arterial and Biliary Complication-Free Survival (ABCFS) have been developed to better assess post-transplant outcomes. Primary objective: To assess, in a large-scale study, whether the procurement technique influences liver transplantation outcomes in terms of arterial and biliary complication-free survival.
Primary outcome measures
- Arterial and Biliary Complication-Free Survival (ABCFS) at 3 years [Time frame: at 3 years post-transplantation]
Secondary outcome measures (7)
- Postoperative complications at 90 days [Time frame: at 90 days post-transplantation]
- Type of Biliary complications [Time frame: Up to 3 years post-transplantation]
- Type of Arterial complications [Time frame: Up to 3 years post-transplantation]
- Occurrence of vascular injuries observed following organ procurement [Time frame: Peri-procedural period (during procurement and immediately post-procurement)]
- Rehospitalization Rate Post-LT [Time frame: Up to 3 years post-transplantation]
- Duration of Rehospitalizations Post-LT [Time frame: Up to 3 years post-transplantation]
- Reasons for Rehospitalizations Post-LT [Time frame: Up to 3 years post-transplantation]
Eligibility criteria
Inclusion criteria
- Patients aged 18 years or older at the time of inclusion
- Listed on the national waiting list of the Agence de la Biomédecine (ABM)
- Undergoing a first liver transplantation in France
- Receiving a whole liver graft
- No prior or subsequent transplantation of another organ
Exclusion criteria
- Pancreas procurement
- Multiorgan transplantation
- Split liver transplantation (shared grafts)
- Retransplantation
- Domino transplantation (no actual organ procurement in the conventional sense)
- Patient refusal to allow the use of their data
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07582978 · APHP250871