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Recruiting NCT07580040

Acute Ocular Effects of Cigarette Smoking

— Observational Smoking ( Cigarette) Cornea Anterior Eye Segment Measurements

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Cigarette Smoking Exposure, No Smoking Exposure.
Who it may be relevant to
Registry conditions: Smoking ( Cigarette), Cornea, Anterior Eye Segment Measurements. Basic parameters: 18 years — 60 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Acute Effects of Cigarette Smoking on Corneal Tomographic and Biometric Parameters: A Prospective Controlled Study

Overview

This prospective study aims to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults. After baseline examinations and measurements are taken in both smoking and non-smoking participants, the same measurements will be repeated after 10 minutes of external exposure, and within-group and between-group changes will be compared. The aim of the study is to determine whether acute smoking exposure leads to measurable immediate changes in corneal tomographic and biometric parameters.

Detailed description

This study is a single-center, prospective, and controlled study designed to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults. The study aimed to include 46 smokers and 46 non-smokers. To avoid inter-eye correlation, only the right eye of each participant was evaluated. All participants initially underwent a full ophthalmological examination and measurements were taken using a Pentacam device. Afterward, all participants waited in standard outdoor conditions for 10 minutes. During this time, participants in the smoking group smoked, while participants in the control group did not smoke. The same measurements were repeated at the end of the period. The study aimed to compare within-group and between-group differences in changes.

Interventions

  • Other Cigarette Smoking Exposure
    Participants in the smoking group smoked cigarettes during a standardized 10-minute outdoor period between baseline and post-exposure assessments.
  • Other No Smoking Exposure
    Participants in the control group remained in the same outdoor environment for 10 minutes without smoking between baseline and post-exposure assessments.

Primary outcome measures

  • Change in Pentacam-measured corneal pachymetry at the pupil center after acute cigarette smoking exposure [Time frame: Baseline and immediately after a standardized 10-minute outdoor exposure period]
Secondary outcome measures (1)
  • Change in Pentacam-measured corneal densitometry in the anterior 0-2 mm zone after acute cigarette smoking exposure [Time frame: Baseline and immediately after a standardized 10-minute outdoor exposure period]

Eligibility criteria

Inclusion criteria

  • Healthy adults aged 18 to 60 years
  • Current smokers in the smoking group
  • Never-smokers in the control group
  • Willing and able to undergo ophthalmic examination and Pentacam AXL measurements

Exclusion criteria

  • History of ocular surgery or ocular trauma
  • Presence of corneal disease, retinal disease, or ocular surface disorder
  • Clinically significant dry eye disease
  • Contact lens use within the last 2 weeks
  • Use of medications that may affect the ocular surface or pupillary dynamics, including anticholinergics or sympathomimetics
  • Systemic diseases such as diabetes mellitus or hypertension
  • Former smoking history in the control group
  • Use of electronic cigarettes or other tobacco products
  • Inability to cooperate adequately for accurate measurement

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

Turkey (Türkiye) · 1 center
  • Istanbul University, Istanbul Faculty of Medicine — Istanbul

Identifiers

NCT: NCT07580040 · IstanbulU-2026-3901546

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗