Impact of Physical Activity During Pregnancy on Biological Markers at Birth in Cord Blood (CORDOMOUV)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: physical activity level during pregnancy.
- Who it may be relevant to
- Registry conditions: New Born. Basic parameters: 1 Day — 2 Days · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Currently, an interventional protocol for physical activity during pregnancy is underway at the Clermont University Hospital (PREGMOUV study). In addition, we have implemented a protocol for 2 years monitoring of children birthed of this study (NEOMOUV study). Recent data from the scientific literature show that a woman's engagement in regular and appropriate physical activity during her pregnancy presents few dangers while ensuring benefits for the mother-baby dyad. Indeed, physical activity reduces maternal complications such as preeclampsia, gestational diabetes and depression and has many advantages for the child with in particular a reduction in the risk of macrosomia then obesity and diabetes. Neonatal sepsis is a major risk factor for childhood mortality. There is strong negative association between cord blood levels of calprotectin and sepsis risk in human newborns with levels of calprotectin at birth are significantly lower in infants that later experience blood-culture-proven late-onset neonatal sepsis. In adults, plasma calprotectin levels increase following acute exercise. However after 4 weeks trainging plasma calprotectin level decrease. So in response to acute exercise, plasma calprotectin levels increase but in contrast, there is a negative association between basal plasma calprotectin levels and regular physical activity. Therefore, we do not know what impact mother' regular physical activity can have on the level of calprotectin in the cord blood. The objective of this project is to investigate the impact of physical activity during pregnancy on calprotectin value at cord blood.
Interventions
- Behavioral physical activity level during pregnancy
Total physical activity time (in MET minutes/week) of pregnant women measured at Trimestry 3 (explanatory variable)
Primary outcome measures
- Calprotectin levels [Time frame: at birth]
Secondary outcome measures (11)
- calprotectin level [Time frame: at birth]
- calprotectin level [Time frame: at birth]
- calprotectin level [Time frame: at birth]
- calprotectin level [Time frame: at birth]
- calprotectin level [Time frame: at birth]
- transcriptomic [Time frame: at birth]
- transciptomic [Time frame: at birth]
- transciptomic [Time frame: at birth]
- transciptomic [Time frame: at birth]
- transciptomic [Time frame: at birth]
- transciptomic [Time frame: at birth]
Eligibility criteria
Inclusion criteria
- Newborns born to mothers who participated in the PregMouv study (which aims to evaluate an intervention allowing women to better adhere to physical activity: program free/face-to-face/videoconference/mixed) and born at the Clermont Ferrand University Hospital.
Exclusion criteria
- If parents refuse to participate or in situations where parents are protected by law, cord blood collection cannot be done.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- CHU de Clermont-Ferrand — Clermont-Ferrand
Identifiers
NCT: NCT07579468 · RNI 2026 FEL · 2026-A00010-51