Dynamic Voltage Mapping to Personalise the Ventricular Tachycardia Substrate
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Dynamic Voltage Mapping, Standard of Care Ablation.
- Who it may be relevant to
- Registry conditions: Ventricular Tachycardia (VT). Basic parameters: 18 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder and one of the commonest causes of heart-related sudden death. It often affects people who have had a heart attack or other structural heart damage. VT occurs when abnormal electrical circuits develop within and around scar tissue in the heart. People at risk are usually offered an implantable cardiac defibrillator (ICD), a device that can detect VT and deliver a lifesaving shock. While effective, these shocks can be sudden, painful and distressing. Medications such as amiodarone can also help, but they are often unsuitable for long-term use due to their potential side effects on the liver, lungs and thyroid gland. An alternative is catheter ablation. Thin tubes (catheters) are threaded from a blood vessel in the groin to the heart, allowing the cardiologist to identify scar tissue and abnormal electrical circuits, which can be destroyed using heat, freezing or electrical energy. Although ablation can help many patients, VT can return in up to one in three people after the procedure. This is because it can be difficult to precisely identify the scar and surrounding tissue that sustain the abnormal circuits, making it challenging to know exactly where to apply ablation treatment. Dynamic Voltage Mapping, is a technique which the investigators believe can more accurately identify scar and the critical bordering tissue during ablation. Initial data collected suggests that the approach accurately predicts the VT circuit and helps guide ablation. In this study, the investigators wish to recruit 40 participants undergoing VT ablation to determine how effective Dynamic Voltage Mapping is in real-world procedures.
Interventions
- Procedure Dynamic Voltage Mapping
Dynamic Voltage Mapping uses electrical information collected from catheters positioned within the heart to create an individualised map of the heart, which the investigators hypothesise will better identify scar and surrounding tissue responsible for ventricular tachycardia. - Procedure Standard of Care Ablation
Standard catheter ablation of ventricular tachycardia, guided by operator preference
Primary outcome measures
- Study Feasibility [Time frame: From enrolment to end of follow up (1 year after procedure)]
Secondary outcome measures (4)
- Procedural Time [Time frame: From start of procedure to end (skin-to-skin)]
- Ablation time/number of lesions [Time frame: From start of procedure to end (skin-to-skin)]
- Acute VT non-inducibility [Time frame: From start of procedure to end (skin-to-skin)]
- VT recurrence Rate [Time frame: From end of procedure to end of follow up (12 months)]
Eligibility criteria
Inclusion criteria
- Scheduled for clinically indicated VT ablation (due to sustained VT episodes or ICD therapies).
- Willing and able to give informed consent for participation in the trial
- Male or female aged between 18-85
- Ischaemic and non-ischaemic cardiomyopathy
- ICD insitu
Exclusion criteria
- Unable or unwilling to consent
- NYHA Class IV (end stage heart failure)
- Metastatic cancer
- End stage renal disease
- Pregnant or breast feeding
- Severe frailty
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United Kingdom · 1 center
- Liverpool Heart and Chest Hospital NHS Foundation Trust — Liverpool
Publications
- Grade Santos J, Mills MT, Calvert P, Worthington N, Phenton C, Modi S, Ashrafi R, Todd D, Waktare J, Mahida S, Gupta D, Luther V. Delineating postinfarct ventricular tachycardia substrate with dynamic voltage mapping in areas of omnipolar vector disarray. Heart Rhythm O2. 2024 Feb 27;5(4):224-233. doi: 10.1016/j.hroo.2024.02.006. eCollection 2024 Apr. PMID 38690145
- Khanra D, Calvert P, Hughes S, Waktare J, Modi S, Hall M, Todd D, Mahida S, Gupta D, Luther V. An approach to help differentiate postinfarct scar from borderzone tissue using Ripple Mapping during ventricular tachycardia ablation. J Cardiovasc Electrophysiol. 2023 Mar;34(3):664-672. doi: 10.1111/jce.15766. Epub 2023 Jan 12. PMID 36478627
- Mills MT, Calvert P, Chiong J, Gupta D, Luther V. Dynamic Voltage Mapping of the Post-infarct Ventricular Tachycardia Substrate: A Practical Technique to Help Differentiate Scar from Borderzone Tissue. Arrhythm Electrophysiol Rev. 2024 Oct 14;13:e16. doi: 10.15420/aer.2024.26. eCollection 2024. PMID 39507206
Identifiers
NCT: NCT07573579 · 35371 · FS/CRTF/25/24865