Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Obesity, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction (HFPEF). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity. The main questions it aims to answer are: Does fat inside the heart muscle decrease after weight loss surgery? Does heart relaxation (diastolic function) improve after surgery? Are changes in heart fat linked to changes in weight, body fat, and blood markers? Participants who are already planning to have weight loss surgery will take part in this study. Participants will: Have a heart CT scan to measure fat in the heart muscle before surgery and about 6 months after surgery Have an ultrasound of the heart (echocardiogram) to check how the heart fills and relaxes Have body composition testing to measure fat and muscle Have blood tests, including routine tests and additional markers related to heart function and metabolism Researchers will compare each participant's results before and after surgery to see if heart fat decreases and if heart function and blood markers improve.
Primary outcome measures
- Change in intramyocardial fat content assessed by cardiac CT [Time frame: Baseline to 6 months]
Secondary outcome measures (6)
- Correlation coefficient between change in intramyocardial fat and change in diastolic function grade [Time frame: Baseline to 6 months]
- Change in diastolic function grade [Time frame: Baseline to 6 months]
- Change in body composition [Time frame: Baseline to 6 months]
- Change in N-terminal pro-B-type natriuretic peptide (NT-proBNP) [Time frame: Baseline to 6 months]
- Change in pericardial fat volume [Time frame: Baseline to 6 months]
- Correlation coefficient between change in intramyocardial fat and change in body weight [Time frame: Baseline to 6 months]
Eligibility criteria
Inclusion criteria
- Adults aged 18 years or older
- Scheduled to undergo bariatric surgery for standard clinical indications
- Left ventricular ejection fraction (LVEF) ≥50%
- Able to undergo cardiac computed tomography (CT)
Exclusion criteria
- Left ventricular ejection fraction (LVEF) <50%
- Known cardiomyopathies, including sarcoidosis, amyloidosis, or myocarditis
- Significant valvular heart disease
- Contraindication to cardiac CT (e.g., severe renal dysfunction, contrast allergy)
- Presence of intracardiac or cardiac-related foreign material that may interfere with imaging (e.g., prosthetic valves, pacemakers, prior transcatheter devices)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07565610 · SZMC-0044-26