Not yet recruiting NCT07560995

Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study

— Observational Multiple Sclerosis Internuclear Ophthalmoplegia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied: This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to: Registry conditions: Multiple Sclerosis, Internuclear Ophthalmoplegia. Basic parameters: from 18 years · All.
What needs checking: Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place: France
Next step: Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS. The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion. The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.

Primary outcome measures

Analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis. [Time frame: 1 year]

Eligibility criteria

Inclusion criteria

Patients with internuclear ophthalmoplegia listed as a primary or associated diagnosis
Patients hospitalized in a neurology department

Exclusion criteria

\- Patients under 18 years of age

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model: Cohort

Study locations

France · 1 center

Les Hôpitaux Universitaires — Strasbourg

Identifiers

NCT: NCT07560995 · CE-2025-86

Primary sources (government registries)

ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗