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Not yet recruiting NCT07558239

Carotid Intima-media Thickness in Dialysis Patients and Traditional Risk Factors

— Observational Dialysis Patients Hypertension Atherosclerosis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Ultrasound measurements of carotid intima- media thickness.
Who it may be relevant to
Registry conditions: Dialysis Patients, Hypertension, Atherosclerosis. Basic parameters: 18 years — 70 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Association of Traditional Cardiovascular and Dialysis-Specific Risk Factors With Carotid Intima-Media Thickness in Hemodialysis Patients: A Cross-Sectional Study"

Overview

* Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients. * Carotid intima-media thickness (CIMT) is a validated surrogate marker for atherosclerosis. * Both traditional cardiovascular risk factors (hypertension, diabetes, dyslipidemia) and dialysis-specific factors (mineral metabolism disorders, dialysis duration) contribute to vascular damage.

Detailed description

* Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients. * Carotid intima-media thickness (CIMT) is a validated surrogate marker for atherosclerosis. * Both traditional cardiovascular risk factors (hypertension, diabetes, dyslipidemia) and dialysis-specific factors (mineral metabolism disorders, dialysis duration) contribute to vascular damage. * Gap in knowledge: Few studies have comprehensively assessed the combined impact of these factors on CIMT in HD patients.

Interventions

  • Other Ultrasound measurements of carotid intima- media thickness
    Ultrasound measurements of carotid intima- media thickness

Primary outcome measures

  • • To determine the association between carotid intima - media thickness and: o Hypertension duration o HbA1c o LDL/HDL ratio o Dialysis duration o Parathyroid hormone (PTH) levels [Time frame: 6 month]
Secondary outcome measures (1)
  • • To compare CIMT between: o Diabetics vs. non-diabetics o Short (<5 yrs) vs. long (≥5 yrs) dialysis duration o Patients with vs. without hyperparathyroidism (PTH >300 pg/m [Time frame: 6month]

Eligibility criteria

Inclusion criteria

  • 1\. Age 18 or older. 2. Patients with sepsis without AKI at the time of admission.

Exclusion criteria

  • o Active malignancy
  • Acute infections
  • Recent cardiovascular events (<3 months)
  • Poor echocardiographic window for CIMT measurement

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Center list to be confirmed — check the primary protocol.

Publications

  • https://doi.org/10.1016/j.atherosclerosis.2019.06.560

Identifiers

NCT: NCT07558239 · 1951/04/2026

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗