Relationship Between Induction Burst Suppression and Bispectral Index
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Bispectral Index Monitoring, Burst Suppression, Total Intravenous Anesthesia. Basic parameters: 18 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Relationship Between Burst Suppression Observed During Anesthesia Induction and the Bispectral Index Value During the Maintenance Phase of Anesthesia
Overview
The purpose of this study is to understand whether certain brain activity patterns that can appear at the beginning of anesthesia are related to how deep anesthesia remains during the operation. The main question of the study is: Do patients who show a pattern called burst suppression during the start of anesthesia experience deeper anesthesia during surgery? Patients who are scheduled for elective surgery under total intravenous anesthesia (TIVA) may take part in this study. During the operation, brain activity will be monitored using a sensor placed on the forehead (Bispectral Index, BIS monitor), which is already commonly used during anesthesia. Information such as BIS values and the doses of anesthesia medications given during the operation will be recorded. Participation in this study will not change the type of anesthesia or the routine care that patients receive during surgery. The study only involves recording and analyzing information collected during standard anesthesia monitoring.
Primary outcome measures
- TBIS<40 [Time frame: During intraoperative period]
Secondary outcome measures (8)
- TBIS40-60 [Time frame: During intraoperative period]
- TBIS>60 [Time frame: During intraoperative period]
- TLOC [Time frame: During induction of anesthesia]
- BIS-LOC [Time frame: At the exact time of loss of consciousness (LOC)]
- TROC [Time frame: During emergence from anesthesia]
- BIS-ROC [Time frame: At the moment of response to verbal commands during emergence from anesthesia]
- Propofol infusion rate during anesthesia [Time frame: During the intraoperative period]
- Remifentanil infusion rate during anesthesia [Time frame: During the intraoperative period]
Eligibility criteria
Inclusion criteria
- Age between 18 and 75 years
- American Society of Anesthesiologists (ASA) physical status I-III
- Scheduled for elective surgery
- Surgery planned to be performed under total intravenous anesthesia (TIVA)
Exclusion criteria
- Presence of neurological disease
- Chronic use of sedative medications or antiepileptic drugs
- Severe hepatic or renal dysfunction
- Intraoperative administration of ketamine or dexmedetomidine
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Turkey (Türkiye) · 2 centers
- Amasya University Sabuncuoglu Serefeddin Training and Research Hospital — Amasya
- Izmir Katip Celebi University Ataturk Training and Research Hospital — Izmir
Identifiers
NCT: NCT07557433 · 2026-82