IOS Parameters and PAP Titration Pressure in Obstructive Sleep Apnea
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Obstructive Sleep Apnea (OSA). Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Impulse Oscillometry for Prediction of PAP Titration Pressure in Obstructive Sleep Apnea (IOS-PAP Study)
Overview
This prospective observational study aims to investigate whether impulse oscillometry (IOS)-a non-invasive lung function test-can help predict the specific pressure settings needed for positive airway pressure (PAP) therapy in patients with obstructive sleep apnea (OSA). Currently, finding the optimal therapeutic pressure for OSA patients typically requires a titration process during sleep. This study explores if IOS parameters, which measure airway resistance and elasticity through small pressure oscillations during normal breathing, correlate with the final titration pressures (CPAP, EPAP, IPAP, and ΔP) determined by polysomnography. Adult patients diagnosed with moderate-to-severe OSA (Apnea-Hypopnea Index ≥ 15) will undergo standard diagnostic sleep testing followed by IOS testing using the Vyaire Vyntus BodyBox® system. The researchers will evaluate whether these respiratory measurements can accurately predict required airway pressures and if they can help clinicians distinguish between patients who need Continuous Positive Airway Pressure (CPAP) versus Bilevel Positive Airway Pressure (BPAP) therapy.
Primary outcome measures
- Correlation between baseline impulse oscillometry (IOS) parameters (R5, X5, and Fres) and optimal CPAP pressure. [Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks)]
Secondary outcome measures (2)
- Discriminative ability of IOS parameters for CPAP versus BPAP treatment allocation. [Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks).]
- Correlation between baseline IOS reactance parameters and bilevel pressure settings (IPAP/EPAP). [Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks).]
Eligibility criteria
Inclusion criteria
- Adults aged 18 to 80 years
- Diagnosed with obstructive sleep apnea (OSA) by overnight polysomnography (PSG)
- Apnea-hypopnea index (AHI) ≥ 15
- Undergoing positive airway pressure (PAP) titration (CPAP or BPAP)
- Able to perform impulse oscillometry (IOS) test
- Provided written informed consent
Exclusion criteria
- Central sleep apnea
- Neuromuscular disease or restrictive lung disease
- Recent upper airway infection (< 2 weeks)
- Incomplete PSG or IOS data
- Inability to cooperate with testing procedures
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Turkey (Türkiye) · 1 center
- Hatay Mustafa Kemal University — Antakya
Identifiers
NCT: NCT07554430 · HMKU-25A002-IOS-PAP · BAP Project No: 25.A.002