Building Cognitive Resilience to Vaccine Misinformation Using AI in Europe
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: AI-driven chatbot, Social media infographic.
- Who it may be relevant to
- Registry conditions: Healthy. Basic parameters: from 20 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Building Cognitive Resilience to Vaccine Misinformation Using Conversational AI: Evidence From a Multi-Country European Randomised Trial
Overview
This multi-country trial evaluates an AI chatbot designed to counter cognitive biases and inoculate parents against vaccine misinformation, embedded within a large survey across five European countries (n=5,000). Scaled from a 2026 single-country study, outcomes compare behavioural and attitudinal responses against standard-of-care materials (e.g., UNICEF infographics) to identify effective, scalable misinformation interventions.
Detailed description
The aim of this multi-country trial is to identify and quantify the effectiveness of inoculation strategies against vaccine-related misinformation. Building on a single-country study implemented in early 2026 \[NCT07488962\], the study evaluates an AI chatbot designed to counter cognitive biases, embedded within a larger survey to enable integrated assessment of engagement, behavioural responses, and system performance at scale.
The study will be conducted across five European countries-the United Kingdom, the Netherlands, Croatia, Latvia, and Slovakia-with a total sample of 5,000 parents or caregivers (n=1,000 per country). Participants will complete a structured survey assessing childhood vaccination behaviours, vaccine confidence, trust in information sources, exposure to misinformation, and relevant psychological and sociodemographic factors.
Participants will be randomly assigned to either the intervention or control arm. The intervention arm will receive the AI-based chatbot, while the control arm will receive standard-of-care materials-such as national or international health institute communications (e.g., UNICEF infographics)-that address the same misinformation messages, enabling a direct and rigorous comparison.
The primary outcome is parents' ability to correctly distinguish true from false childhood vaccine statements. Quantitative analyses will include pooled and country-specific models to identify determinants of vaccine confidence and estimate intervention effects. Findings will clarify drivers of declining vaccine confidence and assess whether a scalable AI-based chatbot can reduce vulnerability to misinformation and support informed vaccination decisions.
Interventions
- Behavioral AI-driven chatbot
A tailored AI-driven chatbot designed to counter vaccine misinformation. - Behavioral Social media infographic
A UNICEF social media infographic with three "myth vs. fact" statements on vaccination.
Primary outcome measures
- Parental susceptibility to misinformation about childhood vaccination [Time frame: Through study completion, an average of 20-30 minutes]
Secondary outcome measures (1)
- Self-efficacy [Time frame: Through study completion, an average of 20-30 minutes]
Eligibility criteria
Inclusion criteria
- Parents or caregivers with children under 18 years old in the five target countries (UK, Netherlands, Croatia, Latvia, and Slovakia); and
- Those who have regular access to a digital device and the internet
Exclusion criteria
- Participants who do not meet the inclusion criteria.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Health services research
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07551986 · LSHTM32877