Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: microneedling with minoxidil 5% and NBUVB, Microneedling with Minoxidil5%.
- Who it may be relevant to
- Registry conditions: Vitiligo - Macular Depigmentation. Basic parameters: 16 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparative Clinical and Histopathological Study of Microneedling With Topical Minoxidil 5% Versus Microneedling With Topical Minoxidil 5% Combined With Narrow-Band Ultraviolet B Phototherapy in the Treatment of Stable Vitiligo
Overview
This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo. It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo. Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact. The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin. The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis
Interventions
- Combination product microneedling with minoxidil 5% and NBUVB
Micronnedlin depth 1% then topical Minoxidil5% and Narrow Band UVB - Combination product Microneedling with Minoxidil5%
Microneedling with topical Minoxidil 5%
Primary outcome measures
- Repigmentation in the vitiliginous area after receiving the treatment and increasing the wnt b catenin marker level in the histopathological specimen [Time frame: From enrollment to the end of treatment at 16 weeks for each patient]
Eligibility criteria
Inclusion criteria
- Patients with stable non-segmental vitiligo
- No new lesions
- No enlargement of existing lesions
- Patients of both sexes
- Age 16 years or older
Exclusion criteria
- Active vitiligo
- Pregnant or lactating women
- History of keloid formation
- Hematological disorders
- Coagulopathies
- Use of anticoagulant therapy
- Use of medications that may prolong bleeding
- Previous vitiligo treatment in the last 2 months
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Factorial
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Abdelghany, n. i., r. s. abdo and W. M. Abdelmaged (2022). "Microneedling in treatment of vitiligo: a review article." Sohag Medical Journal 26(1): 1-7. Bajoria, S., C. R. Srinivas, N. Satish, R. Sukhija, K. Jain, G. Manocha and L. Besra (2025). "Phototherapy with Topical Minoxidil in Vitiligo: A Randomized Control Trial." Indian Dermatol Online J. Elshafy Khashaba, S. A., R. A. Elkot and A. M. Ib
Identifiers
NCT: NCT07548918 · Soh-Med-26-3-5MS