Effectiveness of Dextrose Pleurodesis for the Management of Post-Operative Air Leak
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: 50% Dextrose Pleurodesis, Standard of Care Chest Drainage.
- Who it may be relevant to
- Registry conditions: Post Operative Pulmonary Air Leak. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Dextrose Pleurodesis Versus Standard of Care for the Management of Post-Operative Air Leak: A Single Center Prospective Trial
Overview
A common complication following lung resection surgery is the presence of a post-operative air leak. This occurs when the resected lung tissue does not seal adequately, resulting in continued leakage of air from the lung. For most patient, an air leak will self-resolve by maintaining a drainage catheter in the chest for a prolonged period. However, for some patients, additional measures are required to help seal the affected tissue. Known strategies for managing post-operative air leak include placing one-way valves, surgical revision, and chemical pleurodesis. Chemical pleurodesis involves injecting an irritant through the chest drainage catheter to promote sealing of the leaking lung tissue. While many agents exist for chemical pleurodesis, a relatively new method for treating an air leak is by using dextrose solution. Dextrose is appealing due to low cost and availability. Dextrose solution has shown some efficacy in other countries and undergone Phase 1 clinical investigation in Canada to show its safety and dosing recommendations. In this study, our aim is to compare the effectiveness of using dextrose solution for treating post-operative air leak compared to usual care with chest tube drainage alone.
Interventions
- Drug 50% Dextrose Pleurodesis
A one time intrapleural instillation of 150mL of dextrose will be administered following analgesia with 10mL lidocaine - Other Standard of Care Chest Drainage
maintenance of post operative pulmonary drain without additional intervention
Primary outcome measures
- Time to air leak resolution [Time frame: from randomization to resolution of air leak (<20 mL/min), assessed up to 30 days]
Secondary outcome measures (3)
- Chest tube duration [Time frame: from randomization until chest tube removal, assessed up to 30 days]
- Hospital Length of Stay [Time frame: from randomization until hospital discharge, assessed up to 30 days]
- Adverse Events [Time frame: from randomization through 30 days post-procedure]
Eligibility criteria
Inclusion criteria
- Adult patients who have undergone lung resection
- Persistent post-operative air leak >24 hours after surgery with air leak >20 mL/min
Exclusion criteria
- pregnant patients
- incarcerated patients
- patients with early post-operative complications
- hemodynamic instability
- need for mechanical ventilator support
- high volume chest tube output (>750 mL over 24h)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Qiabi, Mehdi. "PLeurodesis Using hypertonic Glucose administration to treat post-operative air leaks following lung resection surgery (PLUG): Phase I trial." (2021).
- Tsukioka T, Inoue K, Oka H, Mizuguchi S, Morita R, Nishiyama N. Pleurodesis with a 50% glucose solution in patients with spontaneous pneumothorax in whom an operation is contraindicated. Ann Thorac Cardiovasc Surg. 2013;19(5):358-63. doi: 10.5761/atcs.oa.12.01986. Epub 2012 Dec 26. PMID 23269268
- Fujino K, Motooka Y, Koga T, Osumi H, Matsubara E, Shibata H, Ikeda K, Shiraishi K, Mori T, Hayashi K, Yoshimoto K, Wakimoto J, Kubota I, Suzuki M. Novel approach to pleurodesis with 50 % glucose for air leakage after lung resection or pneumothorax. Surg Today. 2016 May;46(5):599-602. doi: 10.1007/s00595-015-1223-2. Epub 2015 Jul 24. PMID 26206407
- Hong JI, Lee JH, Kim HK. Early Pleurodesis for Postoperative Air Leak with Autologous Blood and 50% Glucose Solution. J Chest Surg. 2023 Jan 5;56(1):16-22. doi: 10.5090/jcs.22.096. Epub 2022 Dec 19. PMID 36530129
- Mueller MR, Marzluf BA. The anticipation and management of air leaks and residual spaces post lung resection. J Thorac Dis. 2014 Mar;6(3):271-84. doi: 10.3978/j.issn.2072-1439.2013.11.29. PMID 24624291
- Stephan F, Boucheseiche S, Hollande J, Flahault A, Cheffi A, Bazelly B, Bonnet F. Pulmonary complications following lung resection: a comprehensive analysis of incidence and possible risk factors. Chest. 2000 Nov;118(5):1263-70. doi: 10.1378/chest.118.5.1263. PMID 11083673
- Elsayed H, McShane J, Shackcloth M. Air leaks following pulmonary resection for lung cancer: is it a patient or surgeon related problem? Ann R Coll Surg Engl. 2012 Sep;94(6):422-7. doi: 10.1308/003588412X13171221592258. PMID 22943333
- Dugan KC, Laxmanan B, Murgu S, Hogarth DK. Management of Persistent Air Leaks. Chest. 2017 Aug;152(2):417-423. doi: 10.1016/j.chest.2017.02.020. Epub 2017 Mar 4. PMID 28267436
Identifiers
NCT: NCT07548047 · TJUH-iRISID-2025-0028