Amino Acid Oxidation of Whole-Food Protein: a Dose-Response Crossover Trial in Young Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Food proteins.
- Who it may be relevant to
- Registry conditions: Protein Metabolism. Basic parameters: 18 years — 35 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Netherlands
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this study is to assess the amino acid oxidation dose-response relationship of ingested whole-food protein in healthy adults. In a randomized, crossover design, 20 young, healthy adult males and females aged 18-35 years, will consume a dinner consisting of 0.32, 0.74, and 1.32 g protein･kg BM-1 (corresponding to 1, 2, and 4 minced beef patties, respectively) during 3 separate experimental trials.The main study endpoint is the amino acid oxidation of ingested protein over a 24-h period.
Interventions
- Dietary supplement Food proteins
Dinner meal consisting of minced beef protein.
Primary outcome measures
- Amino acid oxidation of ingested protein [Time frame: Over the 24 hour timeframe following protein ingestion]
Secondary outcome measures (1)
- Plasma amino acid response of ingested protein [Time frame: Over the 24 hour timeframe following protein ingestion]
Eligibility criteria
Inclusion criteria
- Aged between 18-35 years
- BMI between 18.5-30 kg/m2
- Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)
- No physical limitations (i.e., able to perform all activities associated with daily living independently)
Exclusion criteria
- Smoking
- Vegan, vegetarian, or does not consume beef protein
- Diagnosed musculoskeletal disorders
- Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)
- Chronic use of gastric acid-suppressing medication or anti-coagulants
- Unstable weight over the last three months
- Diagnosed GI tract disorders or diseases
- Blood donation in the past 2 months
- Females: pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Netherlands · 1 center
- Maastricht University Medical Centre+ — Maastricht
Identifiers
NCT: NCT07547176 · METC 25-011 · NL-009478