Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: the strengthening program.
- Who it may be relevant to
- Registry conditions: Knee Osteoarthritis (Knee OA). Basic parameters: 55 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis: a Randomized Single-blind Trial of Muscle Training and Knee Orthosis Intervention
Overview
This study aims to examine the effects of moderate-intensity strength training, performed with or without an unloading knee orthosis (valgus-corrective or sham mode), on muscle function, motor unit behavior, and force modulation in patients with moderate knee osteoarthritis
Interventions
- Behavioral the strengthening program
The isometric knee-extension strengthening program from session 1 to session 9 as follows: 1. Before the first training session each week, one-repetition maximum (1RM) will be measured to determine the training intensity for that week. 2. Training frequency: Three sessions per week on non-consecutive days, for a total of 3 weeks (9 sessions). 3. Training intensity: 60% of 1RM. The goal is to improve quadriceps strength and endurance while reducing joint loading. 4. Each session will consist of
Primary outcome measures
- maximal voluntary isometric contraction (MVC) [Time frame: Baseline and 3 weeks]
- The Western Ontario and McMaster Universities Turkish (WOMAC) index [Time frame: baseline, 3 weeks]
- The Knee Injury and Osteoarthritis Outcome Score (KOOS) [Time frame: Baseline and 3 weeks]
- Motor Unit Recruitment (amplitude relative to recruitment threshold) [Time frame: Baseline and 3 weeks]
- Motor Unit Recruitment (firing rate relative to recruitment threshold) [Time frame: Baseline and 3 weeks]
Eligibility criteria
Inclusion criteria
\- 1. age 55 to 75 years.
2\. Diagnosed with moderate knee traumatic arthritis (Kellgren-Lawrence classification II or III)(experimental group).
The control group must not have a diagnosis of osteoarthritis of the knee and must have normal knee joint function.
3\. Physical Health Status: Able to perform basic movements requiring isometric knee contraction tests and electromyography recording.
4\. Able to wear knee orthotics.
Exclusion criteria
- 1\. Knee or lower extremity injury: Recent (within the past 6 months) history of severe injury, fracture, or surgery to the knee or lower extremity.
2\. Other joint disorders: Coexisting joint disorders (such as rheumatoid arthritis or gouty arthritis).
3\. Neuromuscular disorders: Presence of neuromuscular dysfunction, such as stroke, Parkinson's disease, or peripheral neuropathy.
4\. Uncontrolled cardiovascular disease, hypertension, diabetes, or other medical conditions.
Taking medications that affect neuromuscular function.
5\. Allergy or intolerance: Allergy to laboratory equipment (such as electromyography electrode gel) or knee brace materials.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07544693 · A-ER-114-259