Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Gastric Carcinoma, Gastritis Chronic, Intestinal Metaplasia, Gastric Precancerous Lesions. Basic parameters: 18 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Association of Microplastic Exposure With Pathological Stages of Gastric Mucosal Carcinogenesis: A Cross-Sectional Study
Overview
The objective of this clinical trial is to explore the correlation between the level of microplastic exposure and the risk of gastric mucosal carcinogenesis, and to evaluate the strength of its effect as an independent risk factor. The main questions it aims to answer include: Does the level of microplastic exposure increase the risk of gastric mucosal carcinogenesis? Can the correlation between the level of microplastic exposure and gastric mucosal carcinogenesis, as well as the sources of high - risk microplastic exposure, be explored through a questionnaire on external microplastic exposure? Researchers will complete a design structured questionnaire and ask participants to fill it out carefully and truthfully to determine whether the level of microplastic exposure increases the risk of gastric mucosal carcinogenesis.
Detailed description
The study will categorize participants into three groups based on endoscopic and/or histopathological findings: chronic non-atrophic gastritis, precancerous lesions, and gastric cancer. Basic demographic information, \*Helicobacter pylori\* infection status, and plastic exposure assessment scores will be recorded for each group.
Primary outcome measures
- Correlation between external exposure levels of microplastics and three pathological stages of gastric mucosal carcinogenesis [Time frame: 9 months]
Secondary outcome measures (2)
- Analysis of sources of high - risk microplastic exposure [Time frame: 9 months]
- Synergistic toxicity of microplastics and Helicobacter pylori [Time frame: 9 months]
Eligibility criteria
Inclusion criteria
- Aged between 18 and 75 years old, gender is not restricted
- Having a clear diagnosis result within the recent three months and being diagnosed with chronic non - atrophic gastritis, precancerous lesions of gastric cancer, or gastric cancer for the first time
- Have clear Helicobacter pylori (Hp) test results
- Be in normal mental state and able to independently complete the questionnaire survey
Exclusion criteria
- Patients with a history of malignant tumors in other parts
- Patients who have previously undergone upper gastrointestinal surgery, chemotherapy, or radiotherapy
- Patients with severe diseases of major organs such as the heart, lungs liver, and kidneys
- Patients who are currently receiving psychological intervention or taking psychiatric drugs
- Pregnant or lactating women
- Patients with severe missing clinical data or questionnaire information
- Refusing to sign the informed consent form
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
China · 1 center
- Xijing Hosipital of Digestive Disease — Xi'an
Identifiers
NCT: NCT07542652 · KY20262104-F-1