The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No Additional Experimental Intervention.
- Who it may be relevant to
- Registry conditions: Primary Angle-Closure Glaucoma. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Detailed description
This study investigates the pathogenesis of PACG by conducting multi-omics analyses of aqueous humor, blood and anterior lens capsule samples from PACG patients with and without concomitant zonular abnormalities, aiming to elucidate the etiology of zonular abnormalities and uncover novel mechanisms underlying their involvement in the pathogenesis of glaucoma.
Interventions
- Other No Additional Experimental Intervention
No Additional Experimental Intervention
Primary outcome measures
- Concentration of differentially expressed molecules in PACG patients with zonular laxity [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- Clinically diagnosed with primary angle-closure glaucoma (PACG)
- Aged ≥ 50 years, no gender restriction
- Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
- Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
- Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
Exclusion criteria
- Secondary glaucoma
- History of previous intraocular surgery
- Systemic diseases that can cause abnormal ocular zonules
- Other severe ocular diseases
- Long-term use of medications affecting connective tissue metabolism
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- Zhongnan Hospital of Wuhan University — Wuhan
Identifiers
NCT: NCT07539675 · 20260122xrd