Cross Modal Correlation of EEG and MRI Functional Connectivity: An Investigative Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: EEG.
- Who it may be relevant to
- Registry conditions: MRI, Functional MRI. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Israel
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in Functional MRI. The primary aim of this study is to correlate correlation of MRI and EEG.
Detailed description
Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in fMRI. The primary aim of this study is to correlate correlation of MRI and EEG. The expected study duration is approximately 24 months (first patient in to last patient out). Estimated Enrolment: 1500 Subjects.
The aim of this study is to correlate between fMRI and EEG. Overall, the integration of AI into the study of correlations between EEG and fMRI for brain network analysis holds great promise for advancing our understanding of brain function.
Upon consent, eligible participants will be invited for EEG evaluation. EEG will be obtained using a dry electrodes headset. Correlation between fMRI and EEG connectivity for each EEG frequency band across different configurations (brain atlas, EEG connectivity measure).
EEG data will undergo pre-processing of filtering, electrical line noise removal, artifact removal and down sampling. EEG analysis for each state, comprising within and between participant data, will include frequency analysis (peak frequency and relative power), oscillations (proportions of the activity of the alpha, beta, theta, and delta bands) and power spectra distribution. Functional connectivity analysis will be performed including functional coupling.
For evoked response potentials analysis, data will be segmented to trials/epochs. Bad trials will be excluded from analysis. Included trials data will be averaged. Event-related synchronization (ERS) / desynchronization (ERD) will be evaluated.
Interventions
- Diagnostic test EEG
EEG uses small sensors paced on the scalp to record the brain's electrical activity.
Primary outcome measures
- Correlation of fMRI and EEG functional connectivity. [Time frame: The expected study duration is approximately 24 months (first patient in to last patient out)]
Secondary outcome measures (2)
- Correlation between EEG to anatomical MRI findings [Time frame: The expected study duration is approximately 24 months (first patient in to last patient out)]
- Correlation between EEG to clinical diagnosis, cognitive and physical parameters. [Time frame: The expected study duration is approximately 24 months (first patient in to last patient out)]
Eligibility criteria
Inclusion criteria
- Male or females aged 18 years or older.
- Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center
- Able to cooperate in an EEG evaluation
- Can read and sign the informed consent.
Exclusion criteria
- Any scalp/bone abnormality incompatible with the EEG electrodes
- Any known allergy to metals.
- Inability to cooperate with simple instructions.
- Inability to read and sign the informed consent.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Israel · 1 center
- The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh — Zrifin
Identifiers
NCT: NCT07539506 · 0287-23-ASF