Language Function Reorganization in Patients With Arteriovenous Malformations
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: MRI.
- Who it may be relevant to
- Registry conditions: Brain Arteriovenous Malformations. Basic parameters: 18 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Study on the Language Function Reorganization in Right CerebralHemisphere of Patients With Brain Arteriovenous Malformations Using Multimodal MRI
Overview
Brain arteriovenous malformation (AVM) is generally considered as a congenital lesion. Its unique clinical manifestation is that when the unruptured AVM involves and destroys the language function area of the left hemisphere, the patient has almost no language disorder. This phenomenon is distinct from those of acquired diseases such as cerebral infarction and gliomas. There is a hypothesis that it might be associated with that the occurrence of AVM is earlier than period of language learning. Therefore, patients with AVMs involving language areas can be regarded as population whose language areas are congenital "knocked out" but the language functions remain normal, which provide a special model and new insights for language reorganization research. Previous studies have found that the right hemisphere plays an important role in the remodeling of language function in patients with AVMs, but the specific mechanism remains unclear. The purpose of this study is to further elaborate the role of the right cerebral hemisphere in the reorganized language network and the interhemispheric interaction mechanisms in patients with AVMs involving the language areas, using multimodal magnetic resonanceimaging and from multiple dimensions such as functional remodeling, white matter pathway remodeling, structural remodeling, etc., so as to further understand the remodeling mechanism of the Chinese language network after damage of language areas, and also to provide a theoretical basis for the protection of language function in brain network surgery.
Interventions
- Other MRI
All participants underwent MRI scans
Primary outcome measures
- Structural MRI (sMRI) Primary Metric [Time frame: baseline and three months after surgery]
- Functional MRI Secondary Metrics [Time frame: baseline and three months after surgery]
- Diffusion MRI (dMRI) Primary Metrics [Time frame: baseline and three months after surgery]
Secondary outcome measures (1)
- Multimodal Combined & Exploratory Metrics [Time frame: baseline and three months after surgery]
Eligibility criteria
Inclusion criteria
- AVM located within left-hemisphere language regions
- right-handedness
- native Mandarin Chinese speakers
- age 18-60 years
- high school education or above
Exclusion criteria
- comorbid neurological or psychiatric disorders
- AVM-related intracranial hemorrhage within the past month
- prior AVM treatment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China — Beijing
Identifiers
NCT: NCT07537504 · KY2025-104-01