The Effects of a Nurse-led TGA-based Pre-rehabilitation Planning on Perioperative Outcomes in Patients With Liver Cancer: Study and Protocol
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: A nurse-led TGA-based Pre-rehabilitation Planning, ERAS control group.
- Who it may be relevant to
- Registry conditions: Liver Cancer. Basic parameters: 18 years — 84 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The goal of this clinical trial is to to learn if the nurse-led TGA-based Pre-rehabilitation planning can improve compliance, preoperative functional reserve, and reduce the incidence of postoperative complications in patients with hepatocellular carcinoma. The main questions it aims to answer are: 1. Can this pre-rehabilitation program improve patients' perioperative motor function? 2. Can this pre-rehabilitation program enhance patients' perioperative nutritional status? 3. Can this pre-rehabilitation program improve patients' psychological state? 4. Can this pre-rehabilitation program increase patients' overall compliance? Meanwhile, secondary outcome indicators included complication incidence rate, 30-day readmission rate, first anal flatus passage time, hospitalization duration, serum prealbumin, serum albumin, prothrombin time, total bilirubin, satisfaction and quality of Life. Researchers will compare the control group received only ERAS care after the patient's admission to see if the program is effectiveness. Participants who received the intervention group protocol will initiate pre-rehabilitation measures more than 7 days prior to hospital admission, including nutritional support, exercise and respiratory function training, psychological empowerment, pain pre-management, and smoking/alcohol cessation. These interventions will be recorded daily according to the achievement thresholds established by the research team based on outpatient assessment results. After admission, the patients in this group will receive the same EARS care as the control group.
Interventions
- Other A nurse-led TGA-based Pre-rehabilitation Planning
Participants who received the intervention group protocol will initiate pre-rehabilitation measures more than 7 days prior to hospital admission, including nutritional support, exercise and respiratory function training, psychological empowerment, pain pre-management, and smoking/alcohol cessation. These interventions will be recorded daily according to the achievement thresholds established by the research team based on outpatient assessment results. After admission, the patients in this group - Other ERAS control group
Management follows the standard ERAS nursing pathway for hepatoplastic surgery patients, with specific measures including: 1) Preoperative: ① Admission education and preoperative health education; ② Fasting for 2 hours and water restriction for 6 hours prior to surgery; ③ No intestinal preparation; ④ Preoperative administration of carbohydrate solution; ⑤ Guidance on respiratory function exercises; 2) Intraoperative: ① Selection of appropriate anesthesia method; ② No gastric tube placement; ③ Pr
Primary outcome measures
- 6-minute walk test distance [Time frame: Day of admission, Postoperative day 4]
- Prognosis nutrition index [Time frame: Day of admission; Postoperative day 4]
- Anxiety [Time frame: Day of admission, Postoperative day 4]
- Depression [Time frame: Day of admission, Postoperative day 4]
- Overall adherence [Time frame: Day of admission]
Secondary outcome measures (10)
- Complication incidence rate [Time frame: 30 days after discharge]
- 30-day readmission rate [Time frame: 30 days after discharge]
- First anal flatus time [Time frame: Patient reports at the time of their first flatus after surgery]
- Length of hospital stay [Time frame: On the day of discharge]
- Serum prealbumin [Time frame: 1 day before surgery and 4 days after surgery]
- Seralbumin [Time frame: 1 day before surgery and 4 days after surgery]
- Prothrombin time [Time frame: 1 day before surgery and 4 days after surgery]
- Total bilirubin [Time frame: 1 day before surgery and 4 days after surgery]
- Degree of satisfaction [Time frame: Postoperative day 4]
- Quality of life [Time frame: Postoperative day 4]
Eligibility criteria
Inclusion criteria
- (1) Diagnosis of hepatocellular carcinoma based on the Primary Liver Cancer Diagnosis and Treatment Guidelines (2024 Edition) or the Diagnosis Guidelines for Hepatic Metastases of Colorectal Cancer (2025 Edition).
- (2) Patients undergoing elective liver resection after medical evaluation.
- (3) Patients aged from 18-84 years;.
- (4) Voluntary participation in this study.
Exclusion criteria
- (1) Patients with severe cognitive impairment or psychiatric disorders.
- (2) Patients with severe cardiorenal or cerebral organ failure.
- (3) Patients who have participated in other research projects.
- (4) Patients requiring reoperation due to severe postoperative complications.
- (5) Patients who abandon surgical treatment midway.
- (6) Patients who voluntarily discontinue the implementation of prehabilitation programs.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Supportive care
Study locations
China · 1 center
- Fudan University Shanghai Cancer Center — Shanghai
Identifiers
NCT: NCT07537205 · hlb-gzwk-2026-01