Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Rhythmic Auditory Stimulation with music, Rhythmic Auditory Stimulation with metronome, Control.
- Who it may be relevant to
- Registry conditions: Knee Osteoarthritis. Basic parameters: 50 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effects of Music-Based Rhythmic Auditory Stimulation During Walking on Nociceptive Signaling and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis
Overview
The purpose of this research study is to compare muscle activation, changes in pain sensitivity, and brain function, between different walking conditions, including walking to music, walking to metronome, and walking without music or metronome.
Detailed description
Participants with knee osteoarthritis (OA) will complete a single study visit which will include three walking tasks, each being 25 minutes in duration. The walking tasks will include walking without music or metronome, walking to metronome, and walking with music. Participants muscle activity, brain activity, and movements will be recorded during these tasks. Participant's pressure pain threshold will be recorded at the beginning and after each task.
Interventions
- Behavioral Rhythmic Auditory Stimulation with music
Walking to rhythmic Auditory Stimulation with music - Behavioral Rhythmic Auditory Stimulation with metronome
walking to rhythmic Auditory Stimulation with metronome - Behavioral Control
Walking to no music or metronome
Primary outcome measures
- Exercise-Induced Hypoalgesia (EIH) [Time frame: Baseline]
- medial quadriceps - medial hamstrings muscle coactivation [Time frame: Baseline]
Secondary outcome measures (3)
- Medial quadriceps- medial gastrocnemius muscle coactivation [Time frame: Baseline]
- lateral quadriceps- lateral hamstrings muscle coactivation [Time frame: Baseline]
- lateral quadriceps - lateral gastrocnemius muscle coactivation [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Have activity related pain
- Experience morning knee stiffness ≤ 30 minutes
- Knee pain on most days for 3 months or more
- Able to walk at least 20 minutes with assistance
- Average overall knee pain severity of ≥= 4 on a 11-point numeric rating scale during previous week
- BMI ≤ 40
- Able to communicate using English at a level to understand the study procedures and informed consent
Exclusion criteria
- Contraindications to exercise
- Joint replacement in either hip, knee, or ankle
- History of other disease that may involve the index joint including inflammatory joint disease such as rheumatoid arthritis, seronegative spondyloarthropathy (eg, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease related arthropathy), crystalline disease (eg, gout or pseudogout), lupus erythematosus, knee joint infections, Paget's disease affecting the knee, or knee joint tumors.
- Previous knee osteotomy in either knee
- Other health conditions that impact motor functioning or prevent participation (e.g., stroke, Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, diabetic neuropathy, etc.)
- Corticosteroid or hyaluronic acid injections in either knee in the previous 3 months
- Pregnancy (self-report)
- Suspected or known drugs or alcohol abuse
- Mini-mental State Examination (MMSE) score < 24
- Hearing impairments
- Pain in lower back or legs that is greater than knee pain
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07537114 · 8399