Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Chile
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets
Overview
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is: Is the JAK1/2 pathway overactivated in periodontitis compared to health? Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
Detailed description
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
A secondary outcome will be to describe the histological areas, such as epithelium or lamina propria, where the JAK1/2 pathway will be activated including the different subpopulation of cells.
The protocol include one visit where the gingival biopsies are taken.
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants will receive diagnosis and treatment of the gingival condition.
Primary outcome measures
- JAK1/2 pathway activation in gingival tissues [Time frame: Day 1]
Eligibility criteria
Inclusion criteria
- Adults
- Sistemically healthy
Exclusion criteria
- Active Maliganancy
- History of radiation to the head-neck region
- Chemotherapy or radiation within the last 5 years
- History of hepatitis B/C or HIV infection
- Autoimmune diseases
- Diagnosis of diabetes
- Pregnancy or lactation
- More than 3 hospitalizations over the last 3 years
- Use of systemic antibiotics over the last 3 months
- Use of systemic corticosteroids or immunosuppressants over the last 3 months
- Use of cytokine therapy over the last 3 months
- Use of large doses of pre/probiotic supplements over the last 3 months
- Smoke more than 10 cigarettes per day
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Chile · 1 center
- Faculty of Dentistry, University of Chile — Santiago
Identifiers
NCT: NCT07536204 · 2023/11 · 1231350