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Recruiting NCT07535177

Gas6 and Soluble MerTK in Periodontal Diseases

— Observational Periodontitis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: gingival crevicular fluid collection.
Who it may be relevant to
Registry conditions: Periodontitis. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Evaluation of Gas6 and Soluble MerTK Levels in Gingival Crevice Fluid in Individuals With Periodontal Health, Gingivitis, and Periodontitis

Overview

This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.

Interventions

  • Other gingival crevicular fluid collection
    Gingival crevicular fluid collection using sterile paper strips inserted into the gingival sulcus for 30 seconds from selected periodontal sites (healthy, gingivitis, and periodontitis) for biomarker analysis (Gas6 and sMerTK).

Primary outcome measures

  • Gas6 Levels in Gingival Crevicular Fluid [Time frame: baseline]
  • Soluble MerTK (sMerTK) Levels in Gingival Crevicular Fluid [Time frame: baseline]
Secondary outcome measures (4)
  • Plaque Index [Time frame: baseline]
  • Probing Depth [Time frame: baseline]
  • Clinical Attachment Loss [Time frame: baseline]
  • Gingival Index [Time frame: baseline]

Eligibility criteria

Inclusion criteria

  • Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
  • Individuals who have not used antibiotics within the last 3 months
  • Individuals not taking any medications known to affect periodontal tissues
  • Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
  • Individuals with at least 16 natural teeth, excluding third molars
  • Individuals aged 18 years and older

Exclusion criteria

  • Pregnant or lactating individuals
  • Individuals who have received periodontal treatment within the last 6 months
  • Current smokers

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Other

Study locations

Turkey (Türkiye) · 1 center
  • Bolu Abant Izzet Baysal University Faculty of Dentistry — Bolu

Identifiers

NCT: NCT07535177 · BAIBU-SBF-NE-02

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗