MMP-2/3 and Periapical Healing Outcomes
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Nonsurgical Root Canal Treatment.
- Who it may be relevant to
- Registry conditions: Chronic Apical Periodontitis, Periapical Healing. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Association of MMP-2 and MMP-3 Polymorphisms With 12-Month Radiographic Healing After Nonsurgical Root Canal Treatment in Chronic Apical Periodontitis: A Prospective Clinical Study
Overview
This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical periodontitis. A total of 50 patients will undergo standardized endodontic treatment and will be followed for 12 months. Genotyping will be performed using baseline DNA samples, and periapical healing will be assessed using the Periapical Index (PAI). The relationship between genetic variations and treatment outcomes will be analyzed to determine whether host-related genetic factors influence healing patterns after root canal therapy.
Interventions
- Procedure Nonsurgical Root Canal Treatment
All participants will undergo standardized nonsurgical root canal treatment performed under a uniform clinical protocol. After local anesthesia and rubber dam isolation, working length will be determined electronically and radiographically. Root canal preparation will be completed with rotary instrumentation up to size 30/.06, accompanied by sodium hypochlorite irrigation, EDTA, and ultrasonic activation. Canals will then be obturated in the same visit using gutta-percha and epoxy resin-based se
Primary outcome measures
- Radiographic Periapical Healing [Time frame: 12 months after treatment]
Secondary outcome measures (1)
- Association Between MMP Genotypes and Healing Outcomes [Time frame: Baseline (genotyping) and 12 months after treatment]
Eligibility criteria
Inclusion criteria
- Single-rooted teeth
- PAI score ≥ 3
- Fully developed root apices
- Periodontal probing depth less than 5 mm
- Indication for primary nonsurgical root canal treatment
Exclusion criteria
- Previous endodontic treatment in the selected tooth
- Diagnosis of symptomatic apical abscess
- Presence of root fracture or internal/external resorption
- Use of systemic antibiotics within the previous 4 weeks
- Analgesic intake within 48 hours before treatment
- Ongoing immunosuppressive therapy
- Pregnancy or breastfeeding
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07529964 · 3