ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Depressed Mood. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study will evaluate the feasibility and clinical utility of developing predictive models of treatment response for patients with depressed mood using multimodal clinical data collected in real-world clinical settings. The study will examine outcomes among patients treated with interventions including esketamine, conventional transcranial magnetic stimulation (TMS), or Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT). Retrospective clinical and research data from existing databases may also be incorporated, when available and authorized, to support model development and validation. The goal is to assess whether integrated clinical datasets can be used to support the development of predictive tools that may inform personalized treatment selection in depression.
Primary outcome measures
- Patient Health Questionnaire 9-item (PHQ-9) [Time frame: Pre-treatment, Post-treatment, 2 weeks posttreatment, and Monthly post-treatment for 12 months]
Eligibility criteria
Inclusion criteria
- Adults (≥18 years) of any gender identity presenting for care with a depressed mood.
- Prescribed treatment with esketamine, conventional TMS, or SAINT as part of standard clinical care.
- Able to provide informed consent and comply with all study requirements.
Exclusion criteria
- Any condition deemed by the investigator to preclude safe participation in study assessments.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
United States · 2 centers
- Salma Health — La Jolla
- Salma Health — Laguna Hills
Identifiers
NCT: NCT07528014 · SHR-0101