A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Aerobic and resistance exercises.
- Who it may be relevant to
- Registry conditions: Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection. Basic parameters: 21 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Cardiopulmonary, Hemodynamic, And Symptom Responses To Aerobic And Resistance Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia: A Single-center, Single-arm Prospective Clinical Trial.
Overview
The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD).
Interventions
- Behavioral Aerobic and resistance exercises
Subjects will undergo three exercise tests, each separated by at least 48 hours: * Symptom-limited cardiopulmonary exercise test (CPET): Patients will cycle upright starting at 0W (3 min) before the workload is increased by 10-35W·min-1 in a ramp fashion (like cycling up a progressively steeper hill) until volitional exhaustion for the determination of V̇O2peak and Wpeak * Two-stage submaximal constant power exercise test: Following a 5-minute warm-up (10-20 W), participants will cycle in the m
Primary outcome measures
- Change in blood pressure in response to aerobic exercise [Time frame: Baseline, 5 minutes, 25 minutes, 50 minutes and 55 minutes]
- Dartmouth COOP Functional Assessment Chart score [Time frame: Baseline]
- Duke Activity Index Status (DASI) score [Time frame: Baseline]
- International Physical Activity Questionnaire Short Form (IPAQ-SF) score [Time frame: Baseline]
- Change in perceived exertion [Time frame: Baseline, 25 minutes, and 50 minutes]
- Change in blood lactate concentration [La-]b [Time frame: Baseline, 25 minutes, and 50 minutes]
Eligibility criteria
Inclusion criteria
- History of Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain.
- Able to provide written informed consent
Exclusion criteria
- Individuals who are clinically obese (BMI ≥36) and/or who suffer from musculoskeletal or other conditions that would limit exercise participation.
- Individuals who are deemed medically unstable
- Participants who are unable to comply with study requirements.
- Pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Health services research
Study locations
United States · 1 center
- Mayo Clinic in Florida — Jacksonville
Identifiers
NCT: NCT07526766 · 25-011057