Not yet recruiting NCT07514403
Bilogical Assesment During Intrusion of Lower Incisors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Corticision.
- Who it may be relevant to
- Registry conditions: Orthodontic Treatment Efficiency. Basic parameters: 14 years — 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Assessment of the Biological Response of the Corticision During Intrusion of Lower Incisors A Prospective Clinical Study
Overview
biological assesment during intrusion of lower incisors
Detailed description
Assessment of the biological response of the corticision during intrusion of lower incisors A prospective clinical study
Interventions
- Other Corticision
1. Prior panoramic x-ray or serial periapical x-rays are essential to assure the availability of interradicular room to carry out the procedure. 2. Preoperative antiseptic mouthwash is administered to prevent potential infections. 3. Infiltration anesthesia is applied. 4. A reinforced 15T scalpel is positioned on the interradicular attached gingiva at an inclination of 45-60 degrees on the long axis of the tooth to be moved.
Primary outcome measures
- Gingival crevicular fluid (GCF) prostaglandin E2 (PGE2) levels measured by enzyme-linked immunosorbent assay (ELISA) (pg/mL) [Time frame: 12 weeks]
Secondary outcome measures (2)
- Amount of lower incisor intrusion measured in millimeters (mm) using cone beam computed tomography (CBCT) [Time frame: 12 weeks]
- External apical root resorption measured in millimeters (mm) using cone beam computed tomography (CBCT) [Time frame: Time Frame: 12 weeks]
Eligibility criteria
Inclusion criteria
- Patients requiring extraction-based orthodontic treatment
- Presence of deep overbite requiring lower incisor intrusion
- Age range: 18-30 years
- Good general health
- Good oral hygiene
Exclusion criteria
- Systemic diseases affecting bone metabolism
- Previous orthodontic treatment
- Periodontal disease
- Smoking
- Pregnancy or lactation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07514403 · 936/3891