Tetanus Severity Score for Prediction of Mortality in Manifest Tetanus
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Tetanus Severity Score (TSS), Philips Score, Dakar Score.
- Who it may be relevant to
- Registry conditions: Tetanus, Manifest. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparison of Three Scoring Systems for Prediction of Mortality in Patients Admitted to the Intensive Care Unit With Manifest Tetanus
Overview
Three scoring systems will be applied to patients suffering from manifest tetanus and will be related to mortality.
Detailed description
On admission to the intensive care unit, three scoring systems for tetanus severity will be applied to all patients: the Tetanus Severity Score (TSS), Dakar Score, and Philips Score, and will then be related to the occurrence of in-hospital mortality or survival to hospital discharge.
Interventions
- Diagnostic test Tetanus Severity Score (TSS)
The Tetanus Severity Score (TSS) is calculated for each patient by the investigator using the required data as documented in the medical records at admission - Diagnostic test Philips Score
The Philips Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission - Diagnostic test Dakar Score
The Dakar Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission
Primary outcome measures
- Death from any cause. [Time frame: From the date of onset of symptoms until the date of death or date of discharge from the hospital, whichever comes first, assessed up to 90 days.]
Eligibility criteria
Inclusion criteria
- Adults (age 18 years old or more).
- Any sex (male or female), regardless of gender identity.
- Diagnosis of manifest tetanus according to the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus), that is the presence of one or both of the following criteria with or without the history of specific wound or injury:
- Sustained spasm of the facial muscles in which person appears grinning.
- Painful muscular contractions
Exclusion criteria
- Age < 18 years.
- Absent criteria of manifest tetanus, as per the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus).
- Incomplete medical record with missing data required to calculate the Tetanus Severity Score, Philips Score, or Dakar score.
- Incomplete medical record with missing data regarding the primary outcome measure (survival to hospital discharge or in-hospital mortality).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Ain Shams University Hospitals & Demanhour Fever Hospital — Cairo
Identifiers
NCT: NCT07512167 · FMASU MS 433/2025