Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Acute Pain, Postoperative, Chronic Pain, Arthroplasty, Replacement, Knee. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty: A Prospective Observational Study
Overview
This prospective observational study aims to evaluate whether rebound pain after peripheral nerve block is associated with the development of chronic postsurgical pain following elective total knee arthroplasty. Adult patients undergoing unilateral total knee arthroplasty under spinal anesthesia and receiving a peripheral nerve block as part of routine multimodal analgesia will be included. No additional intervention, drug administration, or biological sampling will be performed beyond standard clinical care. Rebound pain will be assessed during the early postoperative period using pain diaries, numeric rating scale pain scores, and analgesic consumption records. Chronic postsurgical pain and related outcomes will be evaluated at postoperative 3 and 6 months using validated instruments assessing pain severity, neuropathic pain features, psychological status, functional outcomes, and health-related quality of life. The primary outcome is the presence of chronic postsurgical pain at 3 months after surgery. Secondary outcomes include chronic pain at 6 months, pain intensity, neuropathic pain characteristics, opioid consumption, rescue analgesic requirements, sleep disturbance, and quality-of-life measures. The study also aims to explore demographic and clinical factors associated with rebound pain and chronic postsurgical pain.
Primary outcome measures
- Presence of Chronic Postsurgical Pain at 3 Months [Time frame: 3 months after surgery]
Secondary outcome measures (2)
- Presence of Chronic Postsurgical Pain at 6 Months assessed by Brief Pain Inventory-Short Form (BPI-SF) interference score [Time frame: 6 months after surgery]
- Pain Intensity in the Early Postoperative Period [Time frame: 0 to 72 hours after surgery]
Eligibility criteria
Inclusion criteria
- Age 18 years or older
- ASA physical status I to III
- Scheduled for unilateral elective total knee arthroplasty
- Planned to undergo spinal anesthesia
- Planned to receive a peripheral nerve block as part of routine multimodal analgesia
- Able to provide informed consent and complete study assessments
Exclusion criteria
- Chronic opioid use (60 mg oral morphine equivalent per day or more, or use for 3 months or longer)
- Significant neuropathy or radiculopathy
- Bilateral or two-stage total knee arthroplasty during the same hospitalization
- Contralateral total knee arthroplasty within the previous 6 months
- Severe cognitive impairment or major psychiatric disorder
- Chronic analgesic dependence
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07511985 · KONYAEH-RA-TDP-2025-01