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Recruiting NCT07504887

Effects of Aerobic Exercise in Rheumatoid Arthritis

No phase Interventional Rheumatic Diseases Rheumatic Disorder

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Standard Medical Care (SMC), Patient Education, Aerobic Exercise Group.
Who it may be relevant to
Registry conditions: Rheumatic Diseases, Rheumatic Disorder. Basic parameters: 30 years — 70 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Evaluation of the Effects of Aerobic Exercise Therapy on Quality of Life, Functional Capacity, Mood, Fatigue, and Inflammatory Markers in Patients With Rheumatoid Arthritis

Overview

This study aims to evaluate the effects of aerobic exercise therapy on quality of life, functional capacity, mood, and fatigue in patients with rheumatoid arthritis. Additionally, the study investigates the impact of aerobic exercise on inflammatory markers, pain, and disease activity.

Detailed description

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by joint inflammation, pain, and functional limitations. Exercise therapy is widely used in rehabilitation to improve functional capacity and quality of life in RA patients.

In this study, patients with low disease activity RA will be divided into two groups:

Standard medical treatment + education Standard medical treatment + education + aerobic exercise

The aerobic exercise program will be conducted 5 days per week for 6 weeks. Outcomes including functional capacity (VO2 max), quality of life, fatigue, mood, and inflammatory markers will be assessed before and after the intervention.

Interventions

  • Other Standard Medical Care (SMC)
    Standard medical treatment
  • Other Patient Education
    Patient education
  • Other Aerobic Exercise Group
    Frequency: 5 days/week Duration: 6 weeks (30 sessions) Exercise intensity: 50-70% of Wmax Includes warm-up, aerobic phase, and cool-down

Primary outcome measures

  • Rheumatoid Arthritis Quality of Life Questionnaire [Time frame: Baseline and at the end of 6 weeks (42th day)]
  • Health Assessment Questionnaire (HAQ) [Time frame: Baseline and at the end of 6 weeks (42th day)]
  • Functional Capacity (Cardiopulmonary Fitness) [Time frame: Baseline and at the end of 6 weeks (42th day)]
  • 6-Minute Walk Test (6MWT) [Time frame: Baseline and at the end of 6th week (42th day)]
Secondary outcome measures (6)
  • Beck Depression Inventory (BDI) [Time frame: Baseline and at the end of 6 weeks (42th day)]
  • Fatigue Severity Scale (FSS) [Time frame: Baseline and after 6 weeks]
  • Visual analogue Scale for pain [Time frame: Baseline and at the end of 6th week (42th day)]
  • Disease Activity Score-28 (DAS-28) [Time frame: Baseline and at the end of 6 weeks (42th day)]
  • Inflammatory Markers [Time frame: Baseline and at the end of 6 weeks (42th day)]
  • The Rheumatoid Arthritis Quality of Life Questionnaire [Time frame: Baseline and at the end of 6th weeks (42th day)]

Eligibility criteria

Inclusion criteria

  • Diagnosed with RA according to ACR/EULAR 2010 criteria
  • Female patients aged 30-70 years
  • Low disease activity (DAS-28 < 3.2)
  • Voluntary participation

Exclusion criteria

  • Cardiovascular diseases (CAD, heart failure, etc.)
  • Respiratory diseases
  • Neurological disorders
  • BMI > 35
  • Malignancy
  • Pregnancy or breastfeeding
  • Recent medication change (last 3 months)
  • Musculoskeletal conditions preventing exercise

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Non-randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Treatment

Study locations

Turkey (Türkiye) · 1 center
  • Kutahya Health Sciences University — Kütahya

Identifiers

NCT: NCT07504887 · Busra tez RA

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗