Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Chatbot counseling, Misinformation-resistance pre-bunking inoculation, Short edutainment, Standard infographic control.
- Who it may be relevant to
- Registry conditions: HPV, HPV Vaccine. Basic parameters: from 27 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Nigeria
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
A Randomized Trial of Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers
Overview
This study evaluates whether different types of digital health communication can increase parents' intention to vaccinate their daughters against human papillomavirus (HPV) in Nigeria. HPV vaccination is recommended for girls aged 9-14 years and helps prevent cervical cancer, yet vaccination rates remain low. Parents of eligible, unvaccinated girls will be randomly assigned to receive one of several types of digital content delivered online. These include: (1) a short chatbot conversation based on motivational interviewing principles, (2) an interactive game designed to help parents recognize and resist common forms of vaccine misinformation, (3) a set of short edutainment videos about HPV vaccination, (4) standard informational infographics about HPV vaccination from a national public health agency, or (5) unrelated health content about menstruation. The main outcome is parents' self-reported intention to vaccinate their daughter against HPV, measured immediately and one week after exposure to the assigned content. Additional outcomes include HPV-related knowledge, perceptions of vaccine safety, willingness to recommend the vaccine to others, and self-reported vaccine uptake at 1-week and 6 month follow-up. The results will help inform scalable communication strategies to improve HPV vaccination uptake in low- and middle-income settings.
Detailed description
Cervical cancer remains a leading cause of cancer-related mortality among women in Nigeria. Persistent infection with high-risk types of human papillomavirus (HPV) is the primary cause of cervical cancer, and safe, effective vaccines are available and recommended for girls aged 9-14 years. Despite national and global efforts to expand access, HPV vaccination coverage in Nigeria remains low. Parental hesitancy, misinformation, limited knowledge, and lack of engagement with existing health communication materials are key barriers.
This randomized controlled trial examines whether different forms of digital communication can increase HPV vaccination intention among parents of unvaccinated, vaccine-eligible girls in Nigeria. The study focuses on scalable, low-cost interventions that could be deployed through mobile phones and other digital platforms.
Eligible participants are parents or primary caregivers of at least one unvaccinated girl aged 9-14 years. Participants will be individually randomized in equal proportions to one of five conditions:
A motivational interviewing-style chatbot that provides brief, interactive counseling adapted from World Health Organization vaccination guidance.
A short interactive "pre-bunking" game designed to build resistance to common forms of HPV vaccine misinformation.
A series of short edutainment videos providing information about HPV, cervical cancer prevention, and HPV vaccination in the Nigerian context.
A standard informational control consisting of existing HPV vaccination infographics produced by Nigeria's National Primary Health Care Development Agency.
An unrelated-content attention control consisting of infographics on menstruation awareness produced by a Nigerian health advocacy organization.
All content will be delivered digitally. Participants will complete baseline measures prior to randomization and follow-up surveys after exposure to the assigned content. The primary outcome is self-reported intention to vaccinate the selected daughter against HPV, measured immediately and one week post-intervention on a numeric scale. Secondary outcomes include HPV and vaccine-related knowledge, perceived vaccine safety, willingness to recommend the HPV vaccine to other parents, and self-reported HPV vaccine uptake. Additional intention measures will be collected 1-week after the intervention and at six months post-intervention, with vaccine uptake assessed at the six-month follow-up.
Primary analyses will be conducted under an intention-to-treat framework, comparing outcomes across randomized groups regardless of engagement with the assigned content. Secondary and exploratory analyses will examine engagement patterns and heterogeneity of effects by baseline attitudes, knowledge, and demographic characteristics.
The findings will provide evidence on the comparative effectiveness of different digital communication strategies for increasing HPV vaccination intention and uptake among parents in Nigeria and similar settings.
Interventions
- Behavioral Chatbot counseling
A brief motivational-interviewing-style chatbot dialogue adapted from WHO vaccination counseling guidance - Behavioral Misinformation-resistance pre-bunking inoculation
A short interactive game (approximately 3-5 minutes) designed to build resistance to HPV vaccine misinformation - Behavioral Short edutainment
5-6 brief edutainment videos (total viewing time approximately 10-15 minutes) providing HPV vaccine information tailored to the Nigerian context - Behavioral Standard infographic control
Existing infographics on HPV vaccination from Nigeria's National Primary Health Care Development Agency (NPHCDA)
Primary outcome measures
- HPV Vaccination Intention (1-Week Post-Intervention) [Time frame: 1 week after exposure to the assigned intervention content]
- HPV Vaccination Intention (Immediately Post-Intervention) [Time frame: Immediately Post-Intervention]
Secondary outcome measures (12)
- HPV Vaccination Intention (6 months post-intervention) [Time frame: 6 months post-intervention]
- Self-Reported HPV Vaccine Uptake [Time frame: 6 months post-intervention]
- Perceived Safety of the HPV Vaccine [Time frame: 1 week post-intervention, 6 months post-intervention]
- Likelihood of Recommending the HPV Vaccine to Other Parents [Time frame: 1 week post-intervention, 6 months post-intervention]
- Self-Reported Knowledge of the HPV Vaccine [Time frame: 1 week post-intervention, 6 months post-intervention]
- Knowledge of the Protective Effects of the HPV Vaccine [Time frame: 1 week post-intervention, 6-months post-intervention]
- Knowledge of Cervical Cancer Detection Methods [Time frame: 1 week post-intervention, 6 months post-intervention]
- Knowledge of HPV Vaccine Eligibility [Time frame: 1 week post-intervention, 6 months post-intervention]
- Perceived Support of HPV Vaccine [Time frame: 1 week post-intervention, 6 months post-intervention]
- Attitudes towards HPV Vaccine [Time frame: 1 week post-intervention, 6 months post-intervention]
- Self-reported Information-seeking behaviors [Time frame: 6 months post-intervention]
- Objective information-seeking behavior [Time frame: 6 months post-intervention]
Eligibility criteria
Inclusion criteria
- Parent or primary caregiver of at least one girl aged 9-14 years
- Parent states "no" or "unsure" to question asking if eligible daughter has received any doses of the HPV vaccine
- Provides informed consent to participate
Exclusion criteria
- Parent or caregiver of a girl who has already received one or more doses of the HPV vaccine
- Does not meet age eligibility criteria for an eligible daughter
- Fails Attention Checks
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Prevention
Study locations
Nigeria · 1 center
- Online study — Lagos
Identifiers
NCT: NCT07498075 · nigeria_hpv_857299