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Not yet recruiting NCT07495917

Tetris Intervention Following Subliminal Reactivation for Intrusive Memories

No phase Interventional Post-traumatic Stress Disorder (PTSD) Intrusive Memories of Traumatic Event(s)

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Subliminal Reactivation, Computer-based Visuospatial Task (Tetris).
Who it may be relevant to
Registry conditions: Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s). Basic parameters: 18 years — 50 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

A Tetris Intervention Following Subliminal Reactivation for Reducing Intrusive Memories in Trauma-exposed Individuals: a Randomized Controlled Trial

Overview

Post-Traumatic Stress Disorder (PTSD) is characterized by recurrent, intrusive memories of traumatic events that cause significant distress and functional impairment. Although trauma-focused treatments are effective, they typically require deliberate recollection of traumatic experiences, which can be distressing and may contribute to treatment avoidance or dropout. In previous experimental studies conducted with healthy participants, we demonstrated that unconscious reactivation of trauma-related cues, followed-after a brief delay corresponding to the memory reconsolidation window-by a visuospatial interference task (Tetris gameplay), reduced the frequency and emotional intensity of intrusive memories. These findings suggest that memory representations may be modifiable during reconsolidation without requiring conscious recall. Building on this work, the present randomized controlled trial (RCT) aims to evaluate the clinical efficacy and tolerability of this reconsolidation-based intervention in trauma-exposed individuals experiencing five or more intrusive memories per week.

Detailed description

This study will be conducted on an online platform, which will be used for data collection, task management, and recording of experimental results. Before recording the baseline diary, each participant will need to provide four images related to their trauma experience for use in subsequent experiments.The provision of these images is voluntary, and participants are fully informed of the intended use of their images.

Interventions

  • Behavioral Subliminal Reactivation
    In each intervention session, participants are exposed subliminally to trauma-related cues and then complete a computerized visuospatial task (Tetris) with mental rotation instructions.
  • Behavioral Computer-based Visuospatial Task (Tetris)
    A computerized visuospatial task (Tetris) with mental rotation instructions.

Primary outcome measures

  • Number of trauma-related intrusive memories [Time frame: Day 66 - 72(all arms) controlling for baseline week]
Secondary outcome measures (9)
  • Number of trauma-related intrusive memories [Time frame: Day 18 - 24 , Day 42 - 48(all arms) controlling for baseline week]
  • Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) [Time frame: Baseline (day 0) and day 73 (all arms)]
  • Intrusive memory ratings [Time frame: Day 24, day 48, day 72, 2 months after the last intervention(all arms)]
  • Post-Intervention Questionnaire [Time frame: Day1, 9, 17, 25, 33, 41, 49, 57, 65 (all arms)]
  • PTSD Checklist for DSM-5 (PCL-5) [Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)]
  • Impact of Event Scale-Revised (IES-R) [Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)]
  • Beck Depression Inventory-II (BDI-II) [Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)]
  • State-Trait Anxiety Inventory-State version (STAI-S) [Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)]
  • Work and Social Adjustment Scale (WSAS) [Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)]

Eligibility criteria

Inclusion criteria

  • Meet DSM-5 PTSD Criterion A (eg, exposure to actual or threatened death). Have experienced one or more traumatic events.
  • Experienced five or more intrusive memories during the baseline week.
  • Have internet access and have access to a personal computer.
  • Be willing to provide consent and able to complete study procedures and be contacted by the study team.

Exclusion criteria

  • Have fewer than five intrusive memories during the baseline week.
  • A current diagnosis of schizophrenia, obsessive-compulsive disorder (OCD), a severe personality disorder judged to interfere with treatment adherence, or acute suicidal behavior.
  • Have severe substance dependence.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07495917 · XAJWKY-2025062

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗