Inhibitory Control and Gait Adaptability in Parkinson's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Parkinson Disease (PD). Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Relationship Between Inhibitory Control and Gait Adaptability During Obstacle Crossing in People With Parkinson's Disease
Overview
People with Parkinson's disease (PD) may have difficulty stopping or changing their movements, especially when walking around obstacles. The goal of this observational study is to learn if a specific cognitive function, called inhibitory control (the ability to stop or control actions) is associated with gait adaptability in people with Parkinson's disease. Gait adaptability means the ability to adjust how a person walks in response to changes in the environment, such as stepping over obstacles. The main questions the study aims to answer are: * If brain activation related to inhibitory control, measured by EEG, is associated with gait adaptability during obstacle crossing in people with Parkinson's disease? * If behavioral inhibitory control is associated with gait adaptability during obstacle crossing in people with Parkinson's disease? Participants take part in one study visit. During this visit, participants complete simple thinking tests, have their brain activity recorded using EEG, and perform walking tasks that include stepping over obstacles.
Primary outcome measures
- Event-related potential - N2 [Time frame: 1 day]
- Event-related potential - P300 [Time frame: 1 day]
- Stroop color and word test [Time frame: 1 day]
- Step width [Time frame: 1 day]
- Stride length/Step length [Time frame: 1 day]
- Single support time [Time frame: 1 day]
- Gait speed [Time frame: 1 day]
- Stride length [Time frame: 1 day]
- Swing phase [Time frame: 1 day]
- Swing width [Time frame: 1 day]
Eligibility criteria
Inclusion criteria
- A clinical diagnosis of idiopathic Parkinson's disease;
- Stable use of prescribed antiparkinsonian medication for at least two weeks;
- Modified Hoehn and Yahr stage I to III;
- Age between 18 and 80 years;
- Ability to ambulate independently for at least 30 meters without assistive devices;
- A Mini-Mental State Examination (MMSE) score of ≥ 24;
- Corrected vision and hearing sufficient to effectively receive external stimuli
Exclusion criteria
- The presence of any neurological, musculoskeletal, or cardiovascular disorders that could affect participation in this study;
- The presence of psychiatric disorders that could interfere with the ability to follow instructions or comply with study procedures;
- A history of brain surgery, such as deep brain stimulation (DBS)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
Taiwan · 2 centers
- National Yang Ming Chiao Tung University — Taipei
- National Yang Ming Chiao Tung University — Taipei
Identifiers
NCT: NCT07494461 · NYCU114252AF1