Recruiting NCT07487649
Treatment Response in Patients With Medication-Overuse Headache
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Treatment outcome.
- Who it may be relevant to
- Registry conditions: Medication-overuse Headache, Treatment, Headache, Greater Occipital Nerve Block. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Factors Affecting Treatment Response in Patients With Medication-Overuse Headache Undergoing Greater Occipital Nerve Blockade
Overview
The aim of this study to evaluate pre-injection patient-related factors that may influence treatment response in patients with medication-overuse headache who underwent ultrasound-guided greater occipital nerve block.
Interventions
- Other Treatment outcome
Before the injection, patients will be evaluated for the number of headache days, headache severity, the number of days of analgesic use for headache, headache-related disability, pressure pain threshold over the bilateral greater occipital nerve, anxiety and depression scores, and sleep quality. At 1 and 2 months after the injection, they will be reassessed for the number of headache days, headache severity, and the number of days of analgesic use for headache. In addition, at 1 hour after the
Primary outcome measures
- the number of days of analgesic use for headache [Time frame: Baseline]
Secondary outcome measures (6)
- Headache severity [Time frame: Baseline]
- Post-injection pain severity [Time frame: Baseline]
- Headache-related disability [Time frame: Baseline]
- Pressure pain threshold [Time frame: Baseline]
- Anxiety and depression levels [Time frame: Baseline]
- Sleep quality [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Age between 18 and 65 years
- Diagnosis of medication-overuse headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)
- Diagnosis of medication-overuse headache associated with the use of triptans or nonsteroidal anti-inflammatory drugs
- Previous diagnosis of chronic migraine or chronic tension-type headache according to the ICHD-3 criteria
Exclusion criteria
- History of severe head or neck trauma or previous neurosurgical intervention
- Presence of a severe psychiatric disorder (e.g., severe depression, schizophrenia)
- History of infectious disease, chronic inflammatory disease, or malignancy
- Previous diagnosis of secondary headache
- History of substance abuse
- Pregnancy or breastfeeding
- History of an additional neurological disorder (e.g., cerebrovascular disease, multiple sclerosis)
- Difficulty with cooperation
- Presence of a concomitant systemic disease that may affect quality of life (e.g., congestive heart failure, chronic kidney disease, chronic liver disease, pulmonary disease, uncontrolled diabetes, or peripheral vascular disease)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
Turkey (Türkiye) · 1 center
- Sultan 1. Murat State Hospital — Edirne
Identifiers
NCT: NCT07487649 · 29/12/2025-Number:13/8