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Not yet recruiting NCT07487324

Oxygenation in Posterior Stabilization Surgery

— Observational Oxygen Oxygen Saturation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: blood gase.
Who it may be relevant to
Registry conditions: Oxygen, Oxygen Saturation. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Factors Determining Oxygenation in Posterior Stabilization Surgery: The Role of Positioning and Mechanical Ventilation Parameters

Overview

This study aims to evaluate the effects of prone positioning on oxygenation, ventilation, and hemodynamic parameters in patients undergoing posterior stabilization surgery under general anesthesia. By comparing routine anesthesia and monitoring data obtained in the supine and prone positions, the study seeks to determine how positional changes influence respiratory mechanics and perioperative physiological stability.

Detailed description

The prone position is frequently used during posterior stabilization surgery, yet it is associated with important physiological changes that may affect both respiratory and hemodynamic function under general anesthesia. Previous studies have shown that prone positioning may improve ventilation-perfusion matching, increase functional residual capacity, and enhance oxygenation. At the same time, position-related alterations in thoracic mechanics, airway pressures, venous return, and cardiovascular parameters may influence intraoperative management.

This study is designed to comprehensively assess the physiological effects of prone positioning in anesthetized patients undergoing posterior stabilization surgery. Routine anesthesia and monitoring data collected during mechanical ventilation will be analyzed and compared between the supine and prone positions. Particular focus will be placed on oxygenation, ventilation variables, respiratory mechanics, and hemodynamic parameters in order to evaluate the impact of positional change.

In addition, the study aims to identify which clinical and monitoring findings should be prioritized during anesthetic management of patients in the prone position. By clarifying the relationship between positioning and perioperative physiological responses, the study seeks to contribute to safer anesthetic practice and to support the maintenance of adequate oxygenation and hemodynamic stability throughout surgery.

Interventions

  • Other blood gase
    Arterial blood gas samples will be obtained from patients, and alveolar oxygenation ratios will be compared between the supine and prone positions.

Primary outcome measures

  • Change in alveolar oxygenation between supine and prone positions [Time frame: within 20 minutes after anesthesia induction]
Secondary outcome measures (1)
  • Change in optic nerve sheath diameter between supine and prone positions [Time frame: intraoperatively]

Eligibility criteria

Inclusion criteria

Patients aged 18 to 75 years Patients classified as ASA physical status I, II, or III according to the American Society of Anesthesiologists Patients undergoing posterior stabilization surgery Patients who voluntarily agreed to participate in the study Patients with a body mass index (BMI) <35 kg/m² Patients followed with a standard mechanical ventilation procedure

Exclusion criteria

  • \- ASA 4 olarak değerlendirilenler
  • Anestezik ajan alerjisi olanlar
  • Kanama diatezi bozukluğu olanlar
  • Cerrahi süresi 3 saatin üstünde olanlar
  • Bilinen ileri akciğer hastalığı olanlar (intertisyel akciğer hastalığı, ileri düzey KOAH, ileri düzey astım vb)
  • VKI≥35 olanlar
  • Obstrüktif uyku apne sendromu tanısı olanlar
  • Toraks deformitesi olanlar
  • Ciddi kalp yetmezliği öyküsü olanlar (EF<30)
  • Şiddetli anemi öyküsü olanlar (Hg<8 mg/dl)
  • Cerrahi operasyon sırasında kan transfüzyonu ihtiyacı olan hastalar

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Turkey (Türkiye) · 1 center
  • Sakarya Universt — Sakarya

Publications

  • Radstrom M, Loswick AC, Bengtsson JP. Respiratory effects of the kneeling prone position for low back surgery. Eur J Anaesthesiol. 2004 Apr;21(4):279-83. doi: 10.1017/s0265021504004053. PMID 15109190

Identifiers

NCT: NCT07487324 · SAU-ANE-EG-01

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗