Phenotypic and Genotypic Detection of Colistin Resistance
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: disk elution test.
- Who it may be relevant to
- Registry conditions: Patients With Multi Drug Resistant Gram-negative Bacteria, Colistin Resistance in Bacteria. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Phenotypic and Genotypic Detection of Colistin Resistance Among Multi Drug Resistant Gram-negative Bacteria in Assiut University Hospital
Overview
* Evaluation of the disk elution test as reliable routine method for detection of colistin resistant among multidrug resistant gram-negative bacteria compared with broth microdilution. * Molecular detection of colistin resistant in multidrug-resistant gram-negative bacteria.
Interventions
- Diagnostic test disk elution test
* Identification of microorganism using conventional methods or Vitek 2 compact system. * Anti biotic susceptibility test using conventional methods or Vitek 2 compact system. * For MDR gram negative bacteria: disc elution test and colistin broth microdilution
Primary outcome measures
- Evaluation of the disk elution test for detection of colistin resistant among multidrug resistant gram-negative bacteria compared with broth microdilution. And Molecular detection of colistin resistant in multidrug-resistant gram-negative bacteria by PCR [Time frame: start from 2026 up to 2029]
Eligibility criteria
Inclusion criteria
-Multidrug-resistant gram-negative isolates will be collected from clinical specimens (blood, urine, sputum, wound swabs, etc.) obtained from hospitalized patients in Assiut University Hospitals.
Exclusion criteria
- gram-positive bacteria
- carbapenem-sensitive gram-negative bacteria
- repeated sample for same patient or different samples from the same patient
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07487116 · Assiut organization