Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Initiation of mechanical ventilation.
- Who it may be relevant to
- Registry conditions: Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation, Acid Base Disorder. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes. The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives: Determine how often acid-base disorders occur in these patients and describe their characteristics. Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm. The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings. This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients. Participation does not involve any intervention, as the study uses existing medical records.
Interventions
- Other Initiation of mechanical ventilation
Blood gases evaluation after initiation of mechanical ventilation
Primary outcome measures
- Acid-base disorder (respiratory acidosis) [Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample]
- Acid-base disorder (respiratory alcalosis) [Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample]
Secondary outcome measures (10)
- Ventilator setting (Respiratory rate) [Time frame: Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample]
- Ventilator setting (Tidal volume) [Time frame: Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample]
- Acid-base disorder (metabolic acidosis) [Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample]
- Acid-base disorder (metabolic alcalosis) [Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample]
- Optimal acid-base result [Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample]
- Mechanical ventilation duration [Time frame: Up to 90 days]
- Vasopressor duration [Time frame: Day 28]
- Hospital length of stay [Time frame: Up to 90 days]
- Mortality [Time frame: Day 28]
- Acute renal failure [Time frame: Up to 90 days. Coronary unit stay - admission through discharge or until death if occured]
Eligibility criteria
Inclusion criteria
- Adult (Age >=18 years old)
- Under mechanical ventilation with endotracheal tube for :
post cardiac arrest or cardiogenic shock
\- Bood gases result availability up to 4 hours after coronary unit admission
Exclusion criteria
- Lack of patient anthropometric data (height and weight) available in the patient record
- No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
- Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Canada · 1 center
- Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval — Québec
Identifiers
NCT: NCT07484828 · 2026-4504