A Retrospective Clinical Study of Metabolic Status and Response to Nutritional Therapy in Patients With Mechanical Ventilation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Mechanical Ventilation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study used a retrospective cohort study based on Multi-time longitudinal monitoring data were used to analyze the correlation mechanism between the dynamic evolution characteristics of nutrition-related biochemical indicators and individualized nutritional intervention in patients with mechanical ventilation. The inflammation-nutrition interaction model was constructed to correct the interference effect of inflammatory microenvironment on nutritional status assessment, so as to provide a basis for further achieving precision nutritional support.
Primary outcome measures
- ICU mortality [Time frame: up to 24 months]
Secondary outcome measures (6)
- Hospital mortality [Time frame: up to 24 months]
- Length of mechanical ventilation [Time frame: up to 24 months]
- Length of ICU stay [Time frame: up to 24 months]
- Length of hospital Stay [Time frame: up to 24 months]
- Incidence of hospital- acquired infections [Time frame: up to 24 months]
- Incidence of gastrointestinal intolerance [Time frame: up to 24 months]
Eligibility criteria
Inclusion criteria
- age ≥18 years old;
- ICU admission ≥72 hours with invasive mechanical ventilation ≥24 hours;
- start nutrition therapy within 72 hours after ICU admission and receive enteral or parenteral nutrition support for ≥3 days;
- Relatively complete nutritional intervention records and nutrition-related biomarkers test results on the 1st, 3rd, and 7th (±1) days of ICU admission;
Exclusion criteria
- women of childbearing age who have a positive pregnancy test, are pregnant or lactating;
- chronic diseases with serious organ function damage or serious complications;
- Kidney: chronic kidney disease stage 4 or 5;
- Liver: previous history of liver failure, hepatic encephalopathy, or hepatic coma, gastrointestinal bleeding due to portal hypertension or Child-Pugh score ≥10 in recent years;
- advanced malignant tumor, or chemotherapy or immunotherapy received within one month before admission;
- severe immunodeficiency or current use of potent immunosuppressive agents, agranulocytosis (N<0.5×10\^9/L), active hematologic malignancies or HIV stage III infection; Patients who were treated with immune-inducing drugs, such as antithymocyte globulin (ATG), antilymphocyte globulin (ALG), interleukin-2 receptor a chain antibody (IL-2RA), interleukin-6 receptor A antibody (IL-6RA); glucocorticoid therapy was continued for nearly 2 weeks, with a daily dose exceeding the hydrocortisone equivalent of 200mg;
- critical illness, death in ICU within 1 week or palliative care only because death outcome was inevitable;
- combined with severe or more severe burns: more than 30% of total body surface area burned or more than 10% of third-degree burn area; Or the total area is less than 30%, but the whole body condition is severe, or there are shock, combined injury, and respiratory tract burn.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07484126 · Metabolic status and nutrition