Long-term Clinical Outcomes After Retinal Artery Occlusion
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: retinal artery occlusion.
- Who it may be relevant to
- Registry conditions: Retinal Artery Occlusion. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Korea
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Long-Term Cardiovascular and Cerebrovascular Outcomes After Retinal Artery Occlusion: A Nationwide Study
Overview
Retinal artery occlusion (RAO) is a rare but vision-threatening vascular disorder that is commonly caused by embolic events originating from the heart or carotid arteries. Patients with RAO are known to have an increased risk of subsequent cardiovascular and cerebrovascular events, including ischemic stroke and myocardial infarction. However, long-term outcomes and optimal medical treatment strategies for these patients remain insufficiently characterized. The purpose of this nationwide population-based study is to investigate the incidence of long-term cardiovascular and cerebrovascular outcomes in patients diagnosed with retinal artery occlusion using the Korean National Health Insurance Service (NHIS) database. In addition, the study aims to evaluate the impact of various medical therapies, including antiplatelet agents, anticoagulants, and statins, on long-term clinical outcomes.
Detailed description
Retinal artery occlusion (RAO) is an acute retinal vascular disease that results in sudden and severe vision loss. RAO is typically classified into central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO), depending on the site of arterial obstruction. CRAO generally has a worse clinical prognosis compared with BRAO.
Previous studies have demonstrated that RAO is associated with systemic vascular diseases and an increased risk of ischemic stroke and other cardiovascular events. Despite its clinical significance, effective evidence-based treatment strategies for RAO remain unclear.
This study aims to evaluate the epidemiology and long-term cardiovascular outcomes of patients with RAO in Korea using the National Health Insurance Service (NHIS) database, which covers nearly the entire Korean population. Patients newly diagnosed with RAO between January 2010 and December 2024 will be identified.
This nationwide population-based study may help clarify the long-term prognosis of RAO and identify optimal medical treatment strategies for improving clinical outcomes in these patients.
Interventions
- Other retinal artery occlusion
treatment for retinal artery occlusion
Primary outcome measures
- Occurrence of MACCE [Time frame: up to 5 years]
Secondary outcome measures (8)
- Occurrence of all-cause death [Time frame: up to 5 years]
- Occurrence of cardiac death [Time frame: up to 5 years]
- Occurrence of myocardial infarction [Time frame: up to 5 years]
- Occurrence of revascularization [Time frame: up to 5 years]
- Occurrence of stroke [Time frame: up to 5 years]
- Occurrence of admission due to heart failure [Time frame: up to 5 years]
- Occurrence of atrial fibrillation [Time frame: up to 5 years]
- Occurrence of major and clinically relevant non-major bleeding [Time frame: up to 5 years]
Eligibility criteria
Inclusion criteria
- Patients newly diagnosed with retinal artery occlusion
Exclusion criteria
- Patients with a prior diagnosis of retinal artery occlusion before the study period.
- Patients diagnosed with giant cell arteritis.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
South Korea · 1 center
- Chonnam National University Hospital — Gwangju
Identifiers
NCT: NCT07482228 · CNUH-EXP-2026-013