Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Cardiac Arrest (CA), Cerebrospinal Fluid, Multiomics, Hypoxic-Ischemic Brain Injury. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Korea
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Identification of Novel Molecular Pathophysiological Mechanisms of Secondary Brain Injury in Post-cardiac Arrest Syndrome Patients Using Cerebrospinal Fluid Multi-omics Analysis
Overview
The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques. The main question this study aims to answer is: Which genome-, transcriptome-, proteome-, and metabolome-level changes in CSF are associated with secondary brain injury after cardiac arrest? To address this question, CSF samples collected from post-cardiac arrest patients will undergo multi-omics analyses. Identified molecular pathways will be used to screen existing drug databases and generate new therapeutic candidates through computational modeling and compound synthesis. These findings will provide the scientific foundation needed to design and implement future preclinical experiments using cardiac arrest animal models.
Primary outcome measures
- Neurological outcome [Time frame: at discharge (assessed up to 3 days), 3 months after return of spontaneous circulation (ROSC)]
Eligibility criteria
Inclusion criteria
- Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment.
- Patients without contraindications for lumbar puncture catheter insertion for cerebrospinal fluid (CSF) collection. This includes the absence of:
- Uncontrolled diabetes.Coagulation disorders.
- Thrombocytopenia (platelet count $< 100,000).
- A history of cirrhosis diagnosis.
- Current receipt of low molecular weight heparin.
- Current use of platelet inhibitors.
- A history of posterior spinal fusion that may interfere with catheter insertion.
- Local skin infection or rash at the puncture site.
- Signs of systemic infection or sepsis.
- A history of lumbar puncture within the past 6 hours.
Exclusion criteria
- Cerebral Edema: Patients with evidence of cerebral edema on a brain computed tomography (CT) scan performed immediately after spontaneous circulation recovery.
- Patients who underwent extracorporeal membrane oxygenation (ECMO).
- Patients who could not maintain integrated therapy for more than 24 hours after cardiac arrest.
- Patients with a history of acute or chronic brain disease.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
South Korea · 1 center
- Chungnam National University Hospital — Daejeon
Publications
- Edgren E, Enblad P, Grenvik A, Lilja A, Valind S, Wiklund L, Hedstrand U, Stjernstrom H, Persson L, Ponten U, Langstrom B. Cerebral blood flow and metabolism after cardiopulmonary resuscitation. A pathophysiologic and prognostic positron emission tomography pilot study. Resuscitation. 2003 May;57(2):161-70. doi: 10.1016/s0300-9572(03)00004-2. PMID 12745184
- Buunk G, van der Hoeven JG, Meinders AE. Cerebral blood flow after cardiac arrest. Neth J Med. 2000 Sep;57(3):106-12. doi: 10.1016/s0300-2977(00)00059-0. No abstract available. PMID 10978556
- Madl C, Holzer M. Brain function after resuscitation from cardiac arrest. Curr Opin Crit Care. 2004 Jun;10(3):213-7. doi: 10.1097/01.ccx.0000127542.32890.fa. PMID 15166839
- Wiklund L, Martijn C, Miclescu A, Semenas E, Rubertsson S, Sharma HS. Central nervous tissue damage after hypoxia and reperfusion in conjunction with cardiac arrest and cardiopulmonary resuscitation: mechanisms of action and possibilities for mitigation. Int Rev Neurobiol. 2012;102:173-87. doi: 10.1016/B978-0-12-386986-9.00007-7. PMID 22748830
Identifiers
NCT: NCT07481396 · CNUH-2025-07-044-003 · RS-2025-00554697