Light Exposure, Migraine Outcomes, and Sleep Quality
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Ambient Lighting Condition.
- Who it may be relevant to
- Registry conditions: Migraine Headache, Sleep, Photophobia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Daily Light Exposure Patterns and Their Associations With Migraine Outcomes and Sleep Quality
Overview
The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.
Detailed description
Migraine is a prevalent neurological disorder that significantly reduces quality of life and daily functioning. Photophobia, or heightened sensitivity to light, is one of the most common and distressing symptoms experienced by individuals with migraine and is frequently reported as a trigger or exacerbating factor for migraine attacks. Additionally, sleep disturbances are commonly associated with migraine and may both contribute to and result from migraine episodes. Despite growing evidence linking light exposure, sleep quality, and migraine characteristics, the role of daily light exposure characteristics in triggering migraine attacks remains poorly understood.
Previous research has largely focused on controlled laboratory studies examining the effects of specific light spectra or intensities during migraine attacks. However, little is known about how individuals with migraine experience and interact with light throughout their daily lives, or how these real-world exposure patterns relate to sleep quality and migraine onset, frequency, and severity.
The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period. The first 4 weeks will serve as a baseline observational period in which participants' daily light exposure behaviors, sleep patterns, and migraine characteristics are monitored. The second four weeks will include the introduction of an interventional lighting condition, optimized for those in migraine based on our previous in-laboratory experiment, on the same outcomes (migraine characteristics and sleep).
Using wearable light exposure sensors, actigraphy devices, and daily self-reported measures, this study aims to capture real-world lighting behaviors and objectively assess sleep quality while evaluating whether the introduction of an optimized lighting condition is associated with changes in migraine symptoms and sleep outcomes.
The specific aims of this study are to:
1. Characterize daily light exposure patterns, including intensity, spectrum, duration, and related behavioral patterns, in adults with migraine with and without photophobia. 2. Examine associations between daily light exposure characteristics and migraine attack onset, frequency, and intensity. 3. Evaluate the feasibility and effectiveness of an optimized lighting condition on migraine frequency, migraine characteristics, and sleep quality.
Interventions
- Other Ambient Lighting Condition
Application of an optimized ambient lighting condition through placement of a dimmable LED floor lamp in participants' private workspaces to create a standardized workplace lighting environment during working hours. The floor lamp emits white light with a specified spectral distribution and intensity. Participants may adjust brightness for comfort. The lighting system is used solely to modify the ambient workplace lighting environment during the 4-week intervention period.
Primary outcome measures
- Change in Monthly Migraine Days [Time frame: Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)]
Secondary outcome measures (7)
- Change in Migraine Headache Intensity [Time frame: Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)]
- Change in Migraine-Specific Quality of Life (MSQ v2.1) Score [Time frame: Baseline (Week 0), Between Baseline and Intervention (end of Week 4), and End of Intervention (Week 8).]
- Change in Objective Sleep Efficiency [Time frame: Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)]
- Change in Average Daily Ambient Light Intensity [Time frame: Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)]
- Feasibility of Workplace Lighting Intervention [Time frame: Intervention Period (Weeks 5-8)]
- Change in Objective Nighttime Sleep Duration [Time frame: Baseline (Weeks 1-4) vs Intervention (Weeks 5-8)]
- Change in Average Daily Melanopic Equivalent Daylight Illuminance [Time frame: Baseline (Weeks 1-4) vs Intervention (Weeks 5-8)]
Eligibility criteria
Inclusion criteria
- Meet the International Classification of Headache Disorders, 3rd edition (2018) criteria for migraine, with or without aura or photosensitivity
- Report experiencing more than 4 headache days per month and at least three migraine attacks per month
- No other major health issues based on self-reported data
- Able to read and communicate in English
- Work in a private office space for at least six hours per day, four days per week
Exclusion criteria
- Light therapy
- Use light-altering devices (e.g., blue-blocking contact lenses or glasses)
- Traveling out of town during the participation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
United States · 1 center
- ASU DeSmart Lab — Tempe
Identifiers
NCT: NCT07476053 · STUDY00023649