From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Pain Management, Perioperative Analgesia, War-Related Injuries. Basic parameters: 18 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Ukraine
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma - A Multicenter Comparative Cohort Study
Overview
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
Detailed description
War-related lower limb trauma represents one of the most frequent and severe injury patterns in modern armed conflicts. Blast injuries, gunshot wounds, and complex soft-tissue damage often result in severe acute pain requiring repeated surgical procedures, prolonged hospitalization, and intensive rehabilitation.
Adequate pain management in this population is critical not only for immediate patient comfort but also for facilitating wound care, early mobilization, rehabilitation participation, and potentially reducing the risk of long-term pain syndromes.
Continuous regional anaesthesia (CRA), delivered through ultrasound-guided peripheral nerve catheters, allows prolonged targeted analgesia by continuous infusion of local anesthetics. Compared with systemic analgesia or single-shot regional blocks, CRA may provide superior and sustained pain control, reduce opioid exposure, and improve rehabilitation tolerance.
However, evidence regarding the effectiveness of continuous regional anaesthesia in war-related lower limb trauma remains limited, particularly in real-world trauma settings involving blast injuries and multi-stage reconstructive surgery.
This study aims to evaluate the effectiveness and safety of continuous regional anaesthesia compared with standard analgesic strategies in patients with war-related lower limb trauma.
Primary outcome measures
- Pain intensity measured by Numeric Rating Scale (NRS 0-10) during the first 72 hours after initiation of analgesic treatment. [Time frame: Pain intensity will be assessed at 6, 12, 24, 48, and 72 hours after initiation of analgesia.]
Secondary outcome measures (1)
- Total opioid consumption during first 72 hours, expressed as morphine milligram equivalents (MME). [Time frame: Cumulative opioid consumption during the first 72 hours after initiation of analgesic therapy.]
Eligibility criteria
Inclusion criteria
- age ≥18 years
- war-related lower limb trauma
- hospital admission requiring surgical treatment or wound management
- documented pain assessment during hospitalization
- availability of analgesic treatment data
- informed consent where required
Exclusion criteria
- age <18 years
- isolated upper limb trauma
- missing key pain outcome data
- contraindication to regional anaesthesia prior to treatment
- refusal to participate (for prospective component)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Ukraine · 1 center
- Superhumans War Trauma Center — Lviv
Publications
- DOI: 10.1016/j.ejvs.2014.07.002
Identifiers
NCT: NCT07474506 · 130301032026 · Superhumans war trauma center