Associations Between Dietary Patterns, LDL Aggregation, and Cardiometabolic Health: A Cross-sectional Analysis.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Atherosclerosis Cardiovascular Disease, Metabolic Syndrome, Dyslipidaemia, Endothelial Dysfunction. Basic parameters: 25 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Associations Between Dietary Pattern Adherence, LDL Aggregation, and Cardiometabolic Health: A Cross-sectional Analysis.
Overview
This study aims to investigate the extent to which vegan or plant-based, omnivorous, and carnivore dietary patterns affect LDL aggregation susceptibility (the affinity for LDL cholesterol particles to clump together in the blood), which may promote plaque build-up in arteries. Using a cross-sectional mixed-methods design, the study will measure LDL aggregation, blood lipids, and other metabolic biomarkers in individuals following these diets, and combine these data with dietary and behavioural information to examine links with cardiovascular and metabolic health.
Primary outcome measures
- LDL aggregation susceptibility [Time frame: Baseline upon enrollment.]
Secondary outcome measures (2)
- Plasma lipid and lipoprotein profile [Time frame: Baseline upon enrollment.]
- Lipoprotein particle size [Time frame: Baseline upon enrollment.]
Eligibility criteria
Inclusion criteria
- Adults aged 25-60 years.
- BMI range (18.5-29.9 kg/m²).
- Following one of the specified dietary patterns (vegan/plant-based, carnivore, or omnivorous) for a minimum of 6 months.
- Self-identified as health-focused (i.e., intentionally following the diet for perceived health benefits).
Exclusion criteria
- BMI outside the stated range (<18.5 or ≥30 kg/m²).
- Use of lipid-lowering medications or supplements that may interfere with LDL levels.
- Pregnancy or breastfeeding.
- Any significant deviation from the specified diet within the last month.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United Kingdom · 1 center
- Tom Reilly Building, Liverpool John Moores University — Liverpool
Identifiers
NCT: NCT07474233 · 260106LJMUREC269