Real-World Effectiveness and Safety of Glofitamab in Primary Refractory and Early Relapsed Diffuse Large B-Cell Lymphoma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: DLBCL - Diffuse Large B Cell Lymphoma. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Efficacy and Safety of Glofitamab in the Real-World Treatment of Patients With Primary Refractory and Early Relapsed Diffuse Large B-Cell Lymphoma
Overview
This is a prospective, observational, non-interventional real-world study that will not alter participants' routine clinical care. Approximately 20 eligible patients with diffuse large B-cell lymphoma (DLBCL) will be enrolled. Treatment decisions will be made by the treating physician based on standard clinical practice and may include glofitamab monotherapy or glofitamab-based combination regimens, such as glofitamab plus gemcitabine and oxaliplatin (Glofit-GemOx) or glofitamab plus polatuzumab-based therapy (Glofit-Pola). The study will collect baseline characteristics (including age, sex, medical history, and molecular subtype), treatment information, laboratory test results, adverse events, and survival follow-up data. Circulating tumor DNA (ctDNA) testing will be performed to assess minimal residual disease (MRD) in peripheral blood. When clinically indicated, cerebrospinal fluid samples may be collected to measure drug concentration. All personal information will be kept strictly confidential. Identifiable information will be removed and replaced with coded study numbers. Medical records will be maintained at the study site and accessed only by authorized research personnel. Representatives from the sponsor, ethics committee, or regulatory authorities may review study records as required. Study results will be published in aggregated form without including any information that could identify individual participants. Study data and personal information will be used solely for research purposes.
Primary outcome measures
- Overall Response Rate (ORR) [Time frame: Up to 6 months]
Secondary outcome measures (7)
- Complete Response Rate (CR Rate) [Time frame: Up to 6 months after enrollment]
- Disease Control Rate (DCR) [Time frame: Up to 6 months after enrollment]
- DoR [Time frame: Up to 24 months]
- Progression-Free Survival (PFS) [Time frame: Up to 24 months]
- Overall Survival (OS) [Time frame: Up to 24 months]
- Incidence of Adverse Events [Time frame: From treatment initiation to 3 months after the last dose]
- Time to Next Treatment (TTNT) [Time frame: Up to 24 months]
Eligibility criteria
Inclusion criteria
- Participants must meet all of the following criteria:
- Age ≥18 years at the time of treatment initiation.
- Histologically or pathologically confirmed diffuse large B-cell lymphoma (DLBCL).
- Patients with primary refractory disease or early relapse, defined as:
Failure to achieve complete response (CR) after at least 4 cycles of first-line induction therapy, or
Relapse confirmed by imaging within 12 months after achieving CR following first-line therapy.
- Patients who plan to initiate a glofitamab-containing treatment regimen (either monotherapy or combination therapy) within 12 months after study initiation.
- Willing and able to comply with study follow-up and data collection requirements.
Exclusion criteria
- Participants meeting any of the following criteria will be excluded:
- Currently participating in, or planning to participate in, any interventional clinical trial.
- Any condition that, in the investigator's judgment, would make the patient unsuitable for participation in this study (e.g., inability to complete follow-up, safety concerns, or significant comorbidities).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Henan cancer hospital — Zhengzhou
Identifiers
NCT: NCT07472621 · 2025-674-IIT-REAL-GLO