Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Control, Intervention.
- Who it may be relevant to
- Registry conditions: Exercise Recovery. Basic parameters: 18 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise . However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects
Interventions
- Dietary supplement Control
Identical maltodextrin tablet. Appearance and weight matched - Dietary supplement Intervention
1,000 mg Vitamin C and 400 mg non-steroidal anti-inflammatory drug every 8-h for 48-h
Primary outcome measures
- Muscle Function [Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)]
Secondary outcome measures (4)
- Muscle Function [Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)]
- Muscle Function [Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)]
- Muscle Function [Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)]
- Creatine Kinase [Time frame: Baseline and immediately, 1-h (hour)-, 2-h-, 24-h-,and 48-hours-post-exercise]
Eligibility criteria
Inclusion criteria
- 18 - 45 years of age
- BMI 18.5 - 29.9 kg/m2
- Able to perform 20-minutes of bench stepping exercise
- Capable and willing to provide consent (oral and written)
Exclusion criteria
- Familiarised with bench stepping exercise procedures
- Not cleared for exercise by health questionnaires or physical activity readiness questionnaire
- Participants exhibiting any alteration in clinical inflammation parameters due to other cause
- Participants currently being prescribed any anti-inflammatory medications
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
United Kingdom · 1 center
- University of Bath — Bath
Identifiers
NCT: NCT07472244 · 11104-14846