Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With PDRN Versus Fractional CO₂ Laser
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Polydeoxyribonucleotide, Fractional CO2 laser assisted PDT.
- Who it may be relevant to
- Registry conditions: Facial Scarring. Basic parameters: 18 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With Polydeoxyribonucleotide (PDRN) Versus Fractional CO₂ Laser: A Randomized Controlled Clinical Study
Overview
Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.
Interventions
- Drug Polydeoxyribonucleotide
intralesional PDRN injections - Device Fractional CO2 laser assisted PDT
Fractional carbon dioxide (CO₂) laser therapy for facial scars
Primary outcome measures
- Vancouver Scar Scale [Time frame: 4 months]
Eligibility criteria
Inclusion criteria
- Age Limitations: Participants must be between 18 and 50 years of age.
- Recently cut wounds or surgical scars from about (1-6 months).
- Consent to Participate: Willingness to provide informed consent and engage in all aspects of the study.
Exclusion criteria
- Pregnancy or breastfeeding at the time of study.
- Known allergy to PDRN.
- Medication use that could affect wound healing or inflammation, such as:
- Isotretinoin.
- Anticancer drugs.
- High-dose corticosteroids.
- Anticoagulants.
- Uncontrolled medical diseases (e.g., unstable diabetes, cardiac conditions).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Misr University for Science and Technology — Giza
Publications
- Kim JH, Jeong JJ, Lee YI, Lee WJ, Lee C, Chung WY, Nam KH, Lee JH. Preventive effect of polynucleotide on post-thyroidectomy scars: A randomized, double-blinded, controlled trial. Lasers Surg Med. 2018 Mar 25. doi: 10.1002/lsm.22812. Online ahead of print. PMID 29574803
Identifiers
NCT: NCT07472192 · 011