Impact of Hypertrophy-oriented Resistance Training on Muscle Mass and Quality of Life in Patients With Unresectable Pancreatic Cancer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: supervised, hypertrophy-oriented strength training program.
- Who it may be relevant to
- Registry conditions: Pancreatic Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Spain
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Impact of Hypertrophy-oriented Resistance Training on Muscle Mass and Quality of Life in Patients With Unresectable Pancreatic Cancer (HY-PANC): Study Protocol for a Randomized Controlled Trial.
Overview
To determine the efficacy of a 12-week supervised, hypertrophy-oriented strength training program in preserving skeletal muscle mass, physical function, and quality of life in patients with unresectable pancreatic cancer compared to standard care.
Detailed description
Two-arm randomized controlled trial will recruit patients with unresectable pancreatic cancer undergoing chemotherapy. Participants will be randomized (1:1) to an Intervention Group (resistance training twice weekly) or a Control Group (standard care). The primary outcome is the change in total lean body mass (assessed by DXA) at week 12. Secondary outcomes include maximal strength, peak power, cardiorespiratory capacity, and patient-reported measures.
Interventions
- Other supervised, hypertrophy-oriented strength training program
12-week supervised, hypertrophy-oriented strength training program in preserving skeletal muscle mass
Primary outcome measures
- Body Composition [Time frame: Through study completion, an average of 1 year]
Secondary outcome measures (3)
- VO2peak [Time frame: Through study completion, an average of 1 year]
- Patient-reported outcome measures [Time frame: Through study completion, an average of 1 year]
- Anxiety and Depression [Time frame: Through study completion, an average of 1 year]
Eligibility criteria
Inclusion criteria
- Diagnosis of locally advanced or metastatic unresectable pancreatic cancer
- Undergoing chemotherapy or immunotherapy treatment
- Age ≥ 18 years
- ECOG score ≤ 2
Exclusion criteria
- Any relative or absolute contraindication that prevents the performance of training or physical tests.
- Diagnosis of other types of primary cancer
- Inability to understand Spanish for proper comprehension of the informed consent and questionnaires
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
Spain · 1 center
- Universidad Europea de Madrid — Madrid
Publications
- Braceras Arias P, Burgos Postigo S, B Alejo L. Impact of Hypertrophy-Oriented Resistance Training on Muscle Mass and Quality of Life in Patients with Unresectable Pancreatic Cancer (HY-PANC): Study Protocol for a Randomized Controlled Trial. Curr Protoc. 2026 Jul;6(7):e70410. doi: 10.1002/cpz1.70410. PMID 42461827
Identifiers
NCT: NCT07470268 · 2026-544