Egg Donation at the Assisted Reproductive Technology (ART) Center of the Nancy University Hospital
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Egg Donation, Infertility Assisted Reproductive Technology. Basic parameters: 18 years — 38 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
DONOVO-Nancy: Egg Donation at the Assisted Reproductive Technology (ART) Center of the Nancy University Hospital: an Overview of the Donor Journey Since the Revisions to the Bioethics Laws
Overview
Since the 2021 revision of French bioethics laws, access to assisted reproductive technologies (ART) has expanded, leading to a significant increase in gamete donation requests. In this context, oocyte donation remains a limited resource, with marked disparities between centers and persistent donor shortages. At the Assisted Reproductive Technology Center of Nancy University Hospital, more than fifty women have initiated an oocyte donation process since the implementation of the new legislation. However, not all candidates complete the donation pathway, and clinical and organizational outcomes have not yet been formally evaluated. This retrospective observational study will evaluate the oocyte donation pathway at the Assisted Reproductive Technology Center of Nancy University Hospital. The study population will include all women who attended a biological consultation for primary or secondary oocyte donation from the implementation of the new Bioethics laws until December 31, 2025 (study period). Baseline clinical and biological characteristics of donor candidates will be described, including age, body mass index, anti-Müllerian hormone level, and antral follicle count. The proportion of donor candidates undergoing oocyte retrieval and the time interval between the first biological consultation and oocyte retrieval will be assessed. Biological and clinical outcomes will also be analyzed, including the number of oocytes retrieved, the number of mature oocytes (metaphase II) obtained, fertilization rate following in vitro fertilization, clinical pregnancy rate per embryo transfer, and live birth rate. Results will be compared with national data reported by the French Biomedicine Agency in order to evaluate the activity and outcomes of the center and to identify potential areas for organizational and clinical improvement in the oocyte donation pathway. The overall objective is to optimize donor management and improve access to oocyte donation for recipient patients.
Primary outcome measures
- Proportion of donor candidates undergoing oocyte retrieval [Time frame: From the first biological consultation until oocyte retrieval, assessed up to 12 months]
Secondary outcome measures (6)
- Mean number of oocytes retrieved per oocyte retrieval procedure [Time frame: At the time of oocyte retrieval procedure, approximately 14-16 days after the start of ovarian stimulation]
- Mean time from first biological consultation to oocyte retrieval [Time frame: From the first biological consultation until oocyte retrieval, assessed up to 12 months]
- Median number of mature oocytes (metaphase II) retrieved per donor [Time frame: At the time of oocyte retrieval procedure, approximately 14-16 days after the start of ovarian stimulation]
- Fertilization rate following in vitro fertilization or intracytoplasmic sperm injection [Time frame: 1 day after fertilization]
- Clinical pregnancy rate per embryo transfer [Time frame: From embryo transfer until confirmation of clinical pregnancy by ultrasound, assessed up to 8 weeks after embryo transfer]
- Live birth rate following oocyte donation cycles [Time frame: From embryo transfer until delivery, assessed up to 41 weeks of gestation]
Eligibility criteria
Inclusion criteria
- All women who attended a biological consultation for primary or secondary oocyte donation at Nancy University Hospital during the study period.
Exclusion criteria
- Absence of biological consultation for oocyte donation during the study period ;
- Insufficient or missing medical data ;
- Documented opposition to data use for research purposes.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- University Hospital of Nancy (CHRU Nancy) — Nancy
Identifiers
NCT: NCT07468331 · 2026PI052