Comparison of Transcutaneous and Blood CO₂ Measurement in Critically Ill Children
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Respiratory Insufficiency in Children. Basic parameters: 1 year — 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Czechia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparison of Transcutaneous Carbon Dioxide Monitoring With Arterialized or Arterial Blood Gas Analysis in PICU
Overview
Transcutaneous capnometry (tPCO₂) is a non-invasive method for continuous monitoring of ventilation status. In pediatric intensive care patients, it may reduce the need for repeated arterial or arterialized blood sampling. However, the accuracy of tPCO₂ may be influenced by factors such as peripheral perfusion, skin temperature, and vasopressor therapy. This prospective observational study compares transcutaneous carbon dioxide measurements with arterialized or arterial blood gas PaCO₂ values in children with respiratory insufficiency, including a subgroup receiving vasopressor support.
Detailed description
This prospective observational study will be conducted in a pediatric intensive care unit to assess agreement between transcutaneous carbon dioxide monitoring and arterialized or arterial blood gas analysis. Consecutive pediatric patients aged 1-18 years with respiratory insufficiency or impaired peripheral perfusion requiring vasopressor support will be included if repeated blood gas sampling is clinically indicated.
Paired measurements of tPCO₂ and PaCO₂ will be analyzed using Bland-Altman methods with correction for repeated measures. Subgroup analyses will evaluate the influence of vasopressor therapy on measurement accuracy. Secondary analyses will compare tPO₂ and PaO₂ values. The study aims to define the clinical applicability and limitations of transcutaneous capnometry in critically ill pediatric patients.
Primary outcome measures
- Partial CO2 difference [Time frame: periprocedural]
Secondary outcome measures (3)
- Proportion of pCO2 [Time frame: periprocedural]
- Partial O2 [Time frame: periprocedural]
- Vassopressor use [Time frame: periprocedural]
Eligibility criteria
Inclusion criteria
- Age 1-18 years
- Diagnosis of respiratory insufficiency or impaired peripheral perfusion
- Expected need for more than one arterialized capillary or arterial blood gas sample
- Admission to PICU
Exclusion criteria
- Repeated failure of sensor adhesion
- Hypothermia < 35 °C
- Time difference > ±5 minutes between tPCO₂ and blood sampling
- Large tPCO₂ variability (> ±1 kPa) in 15 minutes preceding blood sampling
- Non-physiological tPCO₂ values incompatible with life
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Czechia · 1 center
- University Hospital Brno — Brno
Identifiers
NCT: NCT07468006 · SENTEC